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Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review
Soft tissue sarcomas are rare neoplasms, with a high mortality rate. Few drugs are available for the treatment of patients affected by metastatic sarcomas, who still have a 5-years survival rate lower than 20%. However, some of the more recent therapies can obtain long lasting responses in a portion...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629888/ https://www.ncbi.nlm.nih.gov/pubmed/31338321 http://dx.doi.org/10.3389/fonc.2019.00553 |
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author | Pierantoni, Francesco Maruzzo, Marco Brunello, Antonella Chiusole, Benedetta Pusole, Grazia Bezzon, Elisabetta Basso, Umberto Zagonel, Vittorina |
author_facet | Pierantoni, Francesco Maruzzo, Marco Brunello, Antonella Chiusole, Benedetta Pusole, Grazia Bezzon, Elisabetta Basso, Umberto Zagonel, Vittorina |
author_sort | Pierantoni, Francesco |
collection | PubMed |
description | Soft tissue sarcomas are rare neoplasms, with a high mortality rate. Few drugs are available for the treatment of patients affected by metastatic sarcomas, who still have a 5-years survival rate lower than 20%. However, some of the more recent therapies can obtain long lasting responses in a portion of patients, such as Trabectedin. We analyzed four such cases treated at our Institute after progression to an anthracycline based regimen. In each case a therapeutic pause was proposed after at least 6 months of therapy with Trabectedin and in three out of four patients a re-challenge was proposed at progression, achieving again disease control or response. In two cases oligo-progressive sites were treated with localized therapies as stereotactic radiotherapy, delaying the systemic treatment re-start. In this article the reports of the patients involved are presented with a concise review of the relevant literature. Our findings support the favorable safety profile of Trabectedin and the feasibility of drug holidays, which should be at least discussed with the patient. |
format | Online Article Text |
id | pubmed-6629888 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66298882019-07-23 Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review Pierantoni, Francesco Maruzzo, Marco Brunello, Antonella Chiusole, Benedetta Pusole, Grazia Bezzon, Elisabetta Basso, Umberto Zagonel, Vittorina Front Oncol Oncology Soft tissue sarcomas are rare neoplasms, with a high mortality rate. Few drugs are available for the treatment of patients affected by metastatic sarcomas, who still have a 5-years survival rate lower than 20%. However, some of the more recent therapies can obtain long lasting responses in a portion of patients, such as Trabectedin. We analyzed four such cases treated at our Institute after progression to an anthracycline based regimen. In each case a therapeutic pause was proposed after at least 6 months of therapy with Trabectedin and in three out of four patients a re-challenge was proposed at progression, achieving again disease control or response. In two cases oligo-progressive sites were treated with localized therapies as stereotactic radiotherapy, delaying the systemic treatment re-start. In this article the reports of the patients involved are presented with a concise review of the relevant literature. Our findings support the favorable safety profile of Trabectedin and the feasibility of drug holidays, which should be at least discussed with the patient. Frontiers Media S.A. 2019-07-09 /pmc/articles/PMC6629888/ /pubmed/31338321 http://dx.doi.org/10.3389/fonc.2019.00553 Text en Copyright © 2019 Pierantoni, Maruzzo, Brunello, Chiusole, Pusole, Bezzon, Basso and Zagonel. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Pierantoni, Francesco Maruzzo, Marco Brunello, Antonella Chiusole, Benedetta Pusole, Grazia Bezzon, Elisabetta Basso, Umberto Zagonel, Vittorina Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review |
title | Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review |
title_full | Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review |
title_fullStr | Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review |
title_full_unstemmed | Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review |
title_short | Trabectedin Drug Holiday and Rechallenge in Soft Tissue Sarcomas: Report of 4 Cases and Literature Review |
title_sort | trabectedin drug holiday and rechallenge in soft tissue sarcomas: report of 4 cases and literature review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629888/ https://www.ncbi.nlm.nih.gov/pubmed/31338321 http://dx.doi.org/10.3389/fonc.2019.00553 |
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