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Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target
Glutamate transporter-1 (GLT-1) is a Na(+)-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington’s disease (HD), Alzheimer’s disease (AD),...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629900/ https://www.ncbi.nlm.nih.gov/pubmed/31338020 http://dx.doi.org/10.3389/fnmol.2019.00164 |
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author | Peterson, Allison R. Binder, Devin K. |
author_facet | Peterson, Allison R. Binder, Devin K. |
author_sort | Peterson, Allison R. |
collection | PubMed |
description | Glutamate transporter-1 (GLT-1) is a Na(+)-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and epilepsy. Downregulation or dysfunction of GLT-1 has been a common finding across these diseases but how this occurs is still under investigation. This review aims to highlight post-translational regulation of GLT-1 which leads to its downregulation including sumoylation, palmitoylation, nitrosylation, ubiquitination, and subcellular localization. Various therapeutic interventions to restore GLT-1, their proposed mechanism of action and functional effects will be examined as potential treatments to attenuate the neurological symptoms associated with loss or downregulation of GLT-1. |
format | Online Article Text |
id | pubmed-6629900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66299002019-07-23 Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target Peterson, Allison R. Binder, Devin K. Front Mol Neurosci Neuroscience Glutamate transporter-1 (GLT-1) is a Na(+)-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS). GLT-1 dysregulation occurs in various neurological diseases including Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and epilepsy. Downregulation or dysfunction of GLT-1 has been a common finding across these diseases but how this occurs is still under investigation. This review aims to highlight post-translational regulation of GLT-1 which leads to its downregulation including sumoylation, palmitoylation, nitrosylation, ubiquitination, and subcellular localization. Various therapeutic interventions to restore GLT-1, their proposed mechanism of action and functional effects will be examined as potential treatments to attenuate the neurological symptoms associated with loss or downregulation of GLT-1. Frontiers Media S.A. 2019-07-09 /pmc/articles/PMC6629900/ /pubmed/31338020 http://dx.doi.org/10.3389/fnmol.2019.00164 Text en Copyright © 2019 Peterson and Binder. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Peterson, Allison R. Binder, Devin K. Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target |
title | Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target |
title_full | Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target |
title_fullStr | Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target |
title_full_unstemmed | Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target |
title_short | Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target |
title_sort | post-translational regulation of glt-1 in neurological diseases and its potential as an effective therapeutic target |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629900/ https://www.ncbi.nlm.nih.gov/pubmed/31338020 http://dx.doi.org/10.3389/fnmol.2019.00164 |
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