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Environmental Stressors on Skin Aging. Mechanistic Insights
The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particul...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629960/ https://www.ncbi.nlm.nih.gov/pubmed/31354480 http://dx.doi.org/10.3389/fphar.2019.00759 |
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author | Parrado, Concepcion Mercado-Saenz, Sivia Perez-Davo, Azahara Gilaberte, Yolanda Gonzalez, Salvador Juarranz, Angeles |
author_facet | Parrado, Concepcion Mercado-Saenz, Sivia Perez-Davo, Azahara Gilaberte, Yolanda Gonzalez, Salvador Juarranz, Angeles |
author_sort | Parrado, Concepcion |
collection | PubMed |
description | The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). More specifically, we have evaluated ambient air pollution, household air pollutants from non-combustion sources, and exposure to light (ultraviolet radiation and blue and red light). We approach the molecular pathways involved in skin aging and pathology as a result of exposure to these external environmental stressors. Finally, we reflect on how components of environmental stress can interact with ultraviolet radiation to cause cell damage and the critical importance of knowing the mechanisms to develop new therapies to maintain the skin without damage in old age and to repair its diseases. |
format | Online Article Text |
id | pubmed-6629960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66299602019-07-26 Environmental Stressors on Skin Aging. Mechanistic Insights Parrado, Concepcion Mercado-Saenz, Sivia Perez-Davo, Azahara Gilaberte, Yolanda Gonzalez, Salvador Juarranz, Angeles Front Pharmacol Pharmacology The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. This review addresses the impact of environmental stressors on skin aging, especially those related to general and specific external factors (lifestyle, occupation, pollutants, and light exposure). More specifically, we have evaluated ambient air pollution, household air pollutants from non-combustion sources, and exposure to light (ultraviolet radiation and blue and red light). We approach the molecular pathways involved in skin aging and pathology as a result of exposure to these external environmental stressors. Finally, we reflect on how components of environmental stress can interact with ultraviolet radiation to cause cell damage and the critical importance of knowing the mechanisms to develop new therapies to maintain the skin without damage in old age and to repair its diseases. Frontiers Media S.A. 2019-07-09 /pmc/articles/PMC6629960/ /pubmed/31354480 http://dx.doi.org/10.3389/fphar.2019.00759 Text en Copyright © 2019 Parrado, Mercado-Saenz, Perez-Davo, Gilaberte, Gonzalez and Juarranz http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Parrado, Concepcion Mercado-Saenz, Sivia Perez-Davo, Azahara Gilaberte, Yolanda Gonzalez, Salvador Juarranz, Angeles Environmental Stressors on Skin Aging. Mechanistic Insights |
title | Environmental Stressors on Skin Aging. Mechanistic Insights |
title_full | Environmental Stressors on Skin Aging. Mechanistic Insights |
title_fullStr | Environmental Stressors on Skin Aging. Mechanistic Insights |
title_full_unstemmed | Environmental Stressors on Skin Aging. Mechanistic Insights |
title_short | Environmental Stressors on Skin Aging. Mechanistic Insights |
title_sort | environmental stressors on skin aging. mechanistic insights |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629960/ https://www.ncbi.nlm.nih.gov/pubmed/31354480 http://dx.doi.org/10.3389/fphar.2019.00759 |
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