Methotrexate-associated Lymphoproliferative Disorder: A Rare Differential Diagnosis of Wheezes

A 70-year-old woman was admitted for the evaluation of wheezes and a nodular lesion in the left lung field. She had been diagnosed with rheumatoid arthritis at 45 years of age and was continuously treated with methotrexate (MTX) at 8 mg/week. Bronchoscopic aspiration histology of a hilar lymph node...

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Detalles Bibliográficos
Autores principales: Ujino, Mariko, Miyoshi, Shoki, Sugimoto, Naoya, Arai, Hidenori, Ota, Yasunori, Sasajima, Yuko, Kawamura, Masafumi, Nagase, Hiroyuki, Yamaguchi, Masao, Ohta, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630116/
https://www.ncbi.nlm.nih.gov/pubmed/30713294
http://dx.doi.org/10.2169/internalmedicine.2080-18
Descripción
Sumario:A 70-year-old woman was admitted for the evaluation of wheezes and a nodular lesion in the left lung field. She had been diagnosed with rheumatoid arthritis at 45 years of age and was continuously treated with methotrexate (MTX) at 8 mg/week. Bronchoscopic aspiration histology of a hilar lymph node suggested a lymphoproliferative disorder (LPD). After discontinuation of MTX, the lung nodule and wheezes disappeared. Although wheezes are not a usual manifestation of LPD, her clinical course clearly demonstrated an obvious relationship between LPD-induced airway narrowing and wheezes.

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