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Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure
OBJECTIVE: Depression is common in patients with heart failure (HF) and is a possible risk factor for adverse outcomes. The aim of this study was to determine the prevalence of depression assessed by the 2-item Patient Health Questionnaire (PHQ-2) and the effect of depression on outcomes in Japanese...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630118/ https://www.ncbi.nlm.nih.gov/pubmed/30799347 http://dx.doi.org/10.2169/internalmedicine.2034-18 |
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author | Suzuki, Tsuyoshi Shiga, Tsuyoshi Nishimura, Katsuji Omori, Hisako Tatsumi, Fujio Hagiwara, Nobuhisa |
author_facet | Suzuki, Tsuyoshi Shiga, Tsuyoshi Nishimura, Katsuji Omori, Hisako Tatsumi, Fujio Hagiwara, Nobuhisa |
author_sort | Suzuki, Tsuyoshi |
collection | PubMed |
description | OBJECTIVE: Depression is common in patients with heart failure (HF) and is a possible risk factor for adverse outcomes. The aim of this study was to determine the prevalence of depression assessed by the 2-item Patient Health Questionnaire (PHQ-2) and the effect of depression on outcomes in Japanese outpatients with HF. METHODS: This sub-analysis of a prospective observational study assessed 976 patients with HF (mean age 66±13 years; 26.7% female; 42.7% with an ischemic etiology). Depression was defined as a PHQ-2 score ≥3. The main composite outcome was death from any cause or hospitalization due to worsening HF. PHQ-2 items were extracted from the PHQ-9 results. To evaluate the association of PHQ-2 scores with outcomes, Cox proportional hazards models were evaluated. RESULTS: Fifty-seven (5.8%) patients were diagnosed with depression. During a median follow-up of 21 months, the incidence rates for death from any cause and hospitalization due to worsening HF in patients with and without depression were 2.2 vs. 0.9 per 100 person-years and 6.7 vs. 1.6, p<0.001, respectively. There was a higher incidence of the main outcome in patients with depression than in those without depression (p<0.001). After adjustment for conventional risk factors, depression (PHQ-2 ≥3) was an independent predictor of the main outcome (hazard ratio 2.41, 95% confidence interval 1.14-4.67, p=0.022), and a score for item 1 of the PHQ-2 (loss of interest or pleasure) ≥2 was also an independent risk factor (hazard ratio 3.57, 95% confidence interval 1.85-6.46, p<0.001). CONCLUSION: Depression as assessed by the PHQ-2 was identified in 5.8% of Japanese outpatients with HF and was associated with outcomes. |
format | Online Article Text |
id | pubmed-6630118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-66301182019-07-17 Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure Suzuki, Tsuyoshi Shiga, Tsuyoshi Nishimura, Katsuji Omori, Hisako Tatsumi, Fujio Hagiwara, Nobuhisa Intern Med Original Article OBJECTIVE: Depression is common in patients with heart failure (HF) and is a possible risk factor for adverse outcomes. The aim of this study was to determine the prevalence of depression assessed by the 2-item Patient Health Questionnaire (PHQ-2) and the effect of depression on outcomes in Japanese outpatients with HF. METHODS: This sub-analysis of a prospective observational study assessed 976 patients with HF (mean age 66±13 years; 26.7% female; 42.7% with an ischemic etiology). Depression was defined as a PHQ-2 score ≥3. The main composite outcome was death from any cause or hospitalization due to worsening HF. PHQ-2 items were extracted from the PHQ-9 results. To evaluate the association of PHQ-2 scores with outcomes, Cox proportional hazards models were evaluated. RESULTS: Fifty-seven (5.8%) patients were diagnosed with depression. During a median follow-up of 21 months, the incidence rates for death from any cause and hospitalization due to worsening HF in patients with and without depression were 2.2 vs. 0.9 per 100 person-years and 6.7 vs. 1.6, p<0.001, respectively. There was a higher incidence of the main outcome in patients with depression than in those without depression (p<0.001). After adjustment for conventional risk factors, depression (PHQ-2 ≥3) was an independent predictor of the main outcome (hazard ratio 2.41, 95% confidence interval 1.14-4.67, p=0.022), and a score for item 1 of the PHQ-2 (loss of interest or pleasure) ≥2 was also an independent risk factor (hazard ratio 3.57, 95% confidence interval 1.85-6.46, p<0.001). CONCLUSION: Depression as assessed by the PHQ-2 was identified in 5.8% of Japanese outpatients with HF and was associated with outcomes. The Japanese Society of Internal Medicine 2019-02-25 2019-06-15 /pmc/articles/PMC6630118/ /pubmed/30799347 http://dx.doi.org/10.2169/internalmedicine.2034-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Suzuki, Tsuyoshi Shiga, Tsuyoshi Nishimura, Katsuji Omori, Hisako Tatsumi, Fujio Hagiwara, Nobuhisa Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure |
title | Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure |
title_full | Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure |
title_fullStr | Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure |
title_full_unstemmed | Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure |
title_short | Patient Health Questionnaire-2 Screening for Depressive Symptoms in Japanese Outpatients with Heart Failure |
title_sort | patient health questionnaire-2 screening for depressive symptoms in japanese outpatients with heart failure |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630118/ https://www.ncbi.nlm.nih.gov/pubmed/30799347 http://dx.doi.org/10.2169/internalmedicine.2034-18 |
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