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Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice

Background: Inflammatory Bowel Diseases (IBD) encompasses both Crohn’s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). Spearmint (Mentha spicata L.) is a Mediterranean plant used as an aromatic agent, and studies have mainly focused o...

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Autores principales: Direito, Rosa, Rocha, João, Lima, Ana, Gonçalves, Maria Margarida, Duarte, Maria Paula, Mateus, Vanessa, Sousa, Catarina, Fernandes, Adelaide, Pinto, Rui, Boavida Ferreira, Ricardo, Sepodes, Bruno, Figueira, Maria-Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630206/
https://www.ncbi.nlm.nih.gov/pubmed/31174376
http://dx.doi.org/10.3390/medicines6020065
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author Direito, Rosa
Rocha, João
Lima, Ana
Gonçalves, Maria Margarida
Duarte, Maria Paula
Mateus, Vanessa
Sousa, Catarina
Fernandes, Adelaide
Pinto, Rui
Boavida Ferreira, Ricardo
Sepodes, Bruno
Figueira, Maria-Eduardo
author_facet Direito, Rosa
Rocha, João
Lima, Ana
Gonçalves, Maria Margarida
Duarte, Maria Paula
Mateus, Vanessa
Sousa, Catarina
Fernandes, Adelaide
Pinto, Rui
Boavida Ferreira, Ricardo
Sepodes, Bruno
Figueira, Maria-Eduardo
author_sort Direito, Rosa
collection PubMed
description Background: Inflammatory Bowel Diseases (IBD) encompasses both Crohn’s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). Spearmint (Mentha spicata L.) is a Mediterranean plant used as an aromatic agent, and studies have mainly focused on the essential oil suggesting an anti-inflammatory activity. This work aimed to perform a preliminary screening of the in vivo anti-inflammatory effects of a spearmint phenolic extract in an acute inflammation model, in a chronic inflammation model of colitis, and also study the effects in vitro on a colon cancer model. Methods: Spearmint extract was administered to rats of a paw oedema model (induced by carrageenan) and to mice from a TNBS-induced colitis model in parallel with studies using HT-29 CRC cells. Results: Administration of the extract led to reduced paw inflammation, reduction of colon injury and inflammation, with attenuation of histological markers, and reduction of iNOS expression. It repressed the in vitro movement of HT-29 cells in a wound healing assay. Conclusions: These findings suggest that spearmint extract exhibits acute and chronic anti-inflammatory activity and is able to inhibit migration of cancer cells, suggesting a potential role in the supplementary therapy of IBD patients.
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spelling pubmed-66302062019-08-19 Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice Direito, Rosa Rocha, João Lima, Ana Gonçalves, Maria Margarida Duarte, Maria Paula Mateus, Vanessa Sousa, Catarina Fernandes, Adelaide Pinto, Rui Boavida Ferreira, Ricardo Sepodes, Bruno Figueira, Maria-Eduardo Medicines (Basel) Article Background: Inflammatory Bowel Diseases (IBD) encompasses both Crohn’s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). Spearmint (Mentha spicata L.) is a Mediterranean plant used as an aromatic agent, and studies have mainly focused on the essential oil suggesting an anti-inflammatory activity. This work aimed to perform a preliminary screening of the in vivo anti-inflammatory effects of a spearmint phenolic extract in an acute inflammation model, in a chronic inflammation model of colitis, and also study the effects in vitro on a colon cancer model. Methods: Spearmint extract was administered to rats of a paw oedema model (induced by carrageenan) and to mice from a TNBS-induced colitis model in parallel with studies using HT-29 CRC cells. Results: Administration of the extract led to reduced paw inflammation, reduction of colon injury and inflammation, with attenuation of histological markers, and reduction of iNOS expression. It repressed the in vitro movement of HT-29 cells in a wound healing assay. Conclusions: These findings suggest that spearmint extract exhibits acute and chronic anti-inflammatory activity and is able to inhibit migration of cancer cells, suggesting a potential role in the supplementary therapy of IBD patients. MDPI 2019-06-06 /pmc/articles/PMC6630206/ /pubmed/31174376 http://dx.doi.org/10.3390/medicines6020065 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Direito, Rosa
Rocha, João
Lima, Ana
Gonçalves, Maria Margarida
Duarte, Maria Paula
Mateus, Vanessa
Sousa, Catarina
Fernandes, Adelaide
Pinto, Rui
Boavida Ferreira, Ricardo
Sepodes, Bruno
Figueira, Maria-Eduardo
Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice
title Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice
title_full Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice
title_fullStr Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice
title_full_unstemmed Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice
title_short Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice
title_sort reduction of inflammation and colon injury by a spearmint phenolic extract in experimental bowel disease in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630206/
https://www.ncbi.nlm.nih.gov/pubmed/31174376
http://dx.doi.org/10.3390/medicines6020065
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