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Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering
Dynamic light scattering (DLS) is commonly used for the determination of average particle diameters and suspension stability and popular in academics and industry. However, DLS is not considered suitable for polydisperse samples. The presence of little quantities of micrometre particles in nano and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630251/ https://www.ncbi.nlm.nih.gov/pubmed/31159329 http://dx.doi.org/10.3390/nano9060829 |
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author | Ullmann, Christian Babick, Frank Stintz, Michael |
author_facet | Ullmann, Christian Babick, Frank Stintz, Michael |
author_sort | Ullmann, Christian |
collection | PubMed |
description | Dynamic light scattering (DLS) is commonly used for the determination of average particle diameters and suspension stability and popular in academics and industry. However, DLS is not considered suitable for polydisperse samples. The presence of little quantities of micrometre particles in nano and submicrometre suspensions especially affect the reliability of DLS results. Microfiltration might be a suitable method for the removal of unwanted large particles. This study investigates the effect of microfiltration on the diameter distributions as measured by DLS. Polystyrene standards (40–900 nm diameter), and monomodal silica suspensions were filtered with polytetrafluoroethylene (PTFE) membranes (0.1–1.0 µm pore size) to investigate retention properties and grade efficiency. Non-ideal materials were used to prove the results. Experiments showed that a mono-exponential decay can be achieved by filtration. A size safety factor of at least three between labeled pore size and average diameter was found to keep separation as low as possible. Filtration in order to enhance DLS for particulate submicrometre materials was considered suitable for narrowly distributed coated titania and kaolin powder. In a regulatory context, this might have an impact on considering a substance false positive or false negative according to the European Commission (EC) recommendation of a definition of the term nanomaterial. |
format | Online Article Text |
id | pubmed-6630251 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66302512019-08-19 Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering Ullmann, Christian Babick, Frank Stintz, Michael Nanomaterials (Basel) Article Dynamic light scattering (DLS) is commonly used for the determination of average particle diameters and suspension stability and popular in academics and industry. However, DLS is not considered suitable for polydisperse samples. The presence of little quantities of micrometre particles in nano and submicrometre suspensions especially affect the reliability of DLS results. Microfiltration might be a suitable method for the removal of unwanted large particles. This study investigates the effect of microfiltration on the diameter distributions as measured by DLS. Polystyrene standards (40–900 nm diameter), and monomodal silica suspensions were filtered with polytetrafluoroethylene (PTFE) membranes (0.1–1.0 µm pore size) to investigate retention properties and grade efficiency. Non-ideal materials were used to prove the results. Experiments showed that a mono-exponential decay can be achieved by filtration. A size safety factor of at least three between labeled pore size and average diameter was found to keep separation as low as possible. Filtration in order to enhance DLS for particulate submicrometre materials was considered suitable for narrowly distributed coated titania and kaolin powder. In a regulatory context, this might have an impact on considering a substance false positive or false negative according to the European Commission (EC) recommendation of a definition of the term nanomaterial. MDPI 2019-05-31 /pmc/articles/PMC6630251/ /pubmed/31159329 http://dx.doi.org/10.3390/nano9060829 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ullmann, Christian Babick, Frank Stintz, Michael Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering |
title | Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering |
title_full | Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering |
title_fullStr | Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering |
title_full_unstemmed | Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering |
title_short | Microfiltration of Submicron-Sized and Nano-Sized Suspensions for Particle Size Determination by Dynamic Light Scattering |
title_sort | microfiltration of submicron-sized and nano-sized suspensions for particle size determination by dynamic light scattering |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630251/ https://www.ncbi.nlm.nih.gov/pubmed/31159329 http://dx.doi.org/10.3390/nano9060829 |
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