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NMR-Based Metabolomics in Metal-Based Drug Research

Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. I...

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Detalles Bibliográficos
Autores principales: De Castro, Federica, Benedetti, Michele, Del Coco, Laura, Fanizzi, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630333/
https://www.ncbi.nlm.nih.gov/pubmed/31208065
http://dx.doi.org/10.3390/molecules24122240
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author De Castro, Federica
Benedetti, Michele
Del Coco, Laura
Fanizzi, Francesco Paolo
author_facet De Castro, Federica
Benedetti, Michele
Del Coco, Laura
Fanizzi, Francesco Paolo
author_sort De Castro, Federica
collection PubMed
description Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments.
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spelling pubmed-66303332019-08-19 NMR-Based Metabolomics in Metal-Based Drug Research De Castro, Federica Benedetti, Michele Del Coco, Laura Fanizzi, Francesco Paolo Molecules Review Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments. MDPI 2019-06-15 /pmc/articles/PMC6630333/ /pubmed/31208065 http://dx.doi.org/10.3390/molecules24122240 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Castro, Federica
Benedetti, Michele
Del Coco, Laura
Fanizzi, Francesco Paolo
NMR-Based Metabolomics in Metal-Based Drug Research
title NMR-Based Metabolomics in Metal-Based Drug Research
title_full NMR-Based Metabolomics in Metal-Based Drug Research
title_fullStr NMR-Based Metabolomics in Metal-Based Drug Research
title_full_unstemmed NMR-Based Metabolomics in Metal-Based Drug Research
title_short NMR-Based Metabolomics in Metal-Based Drug Research
title_sort nmr-based metabolomics in metal-based drug research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630333/
https://www.ncbi.nlm.nih.gov/pubmed/31208065
http://dx.doi.org/10.3390/molecules24122240
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