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NMR-Based Metabolomics in Metal-Based Drug Research
Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. I...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630333/ https://www.ncbi.nlm.nih.gov/pubmed/31208065 http://dx.doi.org/10.3390/molecules24122240 |
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author | De Castro, Federica Benedetti, Michele Del Coco, Laura Fanizzi, Francesco Paolo |
author_facet | De Castro, Federica Benedetti, Michele Del Coco, Laura Fanizzi, Francesco Paolo |
author_sort | De Castro, Federica |
collection | PubMed |
description | Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments. |
format | Online Article Text |
id | pubmed-6630333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66303332019-08-19 NMR-Based Metabolomics in Metal-Based Drug Research De Castro, Federica Benedetti, Michele Del Coco, Laura Fanizzi, Francesco Paolo Molecules Review Thanks to recent advances in analytical technologies and statistical capabilities, the application field of metabolomics has increased significantly. Currently, this approach is used to investigate biological substrates looking for metabolic profile alterations, diseases markers, and drug effects. In particular, NMR spectroscopy has shown great potential as a detection technique, mainly for the ability to detect multiple (10s to 100s) metabolites at once without separation. Only in recent years has the NMR-based metabolomic approach been extended to investigate the cell metabolic alterations induced by metal-based antitumor drug administration. As expected, these studies are mainly focused on platinum complexes, but some palladium and ruthenium compounds are also under investigation. The use of a metabolomics approach was very effective in assessing tumor response to drugs and providing insights into the mechanism of action and resistance. Therefore, metabolomics may open new perspectives into the development of metal-based drugs. In particular, it has been shown that NMR-based, in vitro metabolomics is a powerful tool for detecting variations of the cell metabolites induced by the metal drug exposure, thus offering also the possibility of identifying specific markers for in vivo monitoring of tumor responsiveness to anticancer treatments. MDPI 2019-06-15 /pmc/articles/PMC6630333/ /pubmed/31208065 http://dx.doi.org/10.3390/molecules24122240 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Castro, Federica Benedetti, Michele Del Coco, Laura Fanizzi, Francesco Paolo NMR-Based Metabolomics in Metal-Based Drug Research |
title | NMR-Based Metabolomics in Metal-Based Drug Research |
title_full | NMR-Based Metabolomics in Metal-Based Drug Research |
title_fullStr | NMR-Based Metabolomics in Metal-Based Drug Research |
title_full_unstemmed | NMR-Based Metabolomics in Metal-Based Drug Research |
title_short | NMR-Based Metabolomics in Metal-Based Drug Research |
title_sort | nmr-based metabolomics in metal-based drug research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630333/ https://www.ncbi.nlm.nih.gov/pubmed/31208065 http://dx.doi.org/10.3390/molecules24122240 |
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