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Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis

Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interl...

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Autores principales: Mozaffari, Hamid Reza, Molavi, Maryam, Lopez-Jornet, Pia, Sadeghi, Masoud, Safaei, Mohsen, Imani, Mohammad Moslem, Sharifi, Roohollah, Moradpoor, Hedaiat, Golshah, Amin, Jamshidy, Ladan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630336/
https://www.ncbi.nlm.nih.gov/pubmed/31181785
http://dx.doi.org/10.3390/medicina55060257
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author Mozaffari, Hamid Reza
Molavi, Maryam
Lopez-Jornet, Pia
Sadeghi, Masoud
Safaei, Mohsen
Imani, Mohammad Moslem
Sharifi, Roohollah
Moradpoor, Hedaiat
Golshah, Amin
Jamshidy, Ladan
author_facet Mozaffari, Hamid Reza
Molavi, Maryam
Lopez-Jornet, Pia
Sadeghi, Masoud
Safaei, Mohsen
Imani, Mohammad Moslem
Sharifi, Roohollah
Moradpoor, Hedaiat
Golshah, Amin
Jamshidy, Ladan
author_sort Mozaffari, Hamid Reza
collection PubMed
description Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. Materials and Methods: The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. Results: The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.22 (95% CI: −1.16, 0.72; p = 0.64) and 0.17 (95% CI: −1.50, 1.84; p = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.15 (95% CI: −0.53, 0.23; p = 0.43) and −0.39 (95% CI: −0.63, −0.15; p = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. Conclusions: In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity.
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spelling pubmed-66303362019-08-19 Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis Mozaffari, Hamid Reza Molavi, Maryam Lopez-Jornet, Pia Sadeghi, Masoud Safaei, Mohsen Imani, Mohammad Moslem Sharifi, Roohollah Moradpoor, Hedaiat Golshah, Amin Jamshidy, Ladan Medicina (Kaunas) Review Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. Materials and Methods: The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. Results: The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.22 (95% CI: −1.16, 0.72; p = 0.64) and 0.17 (95% CI: −1.50, 1.84; p = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were −0.15 (95% CI: −0.53, 0.23; p = 0.43) and −0.39 (95% CI: −0.63, −0.15; p = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. Conclusions: In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity. MDPI 2019-06-08 /pmc/articles/PMC6630336/ /pubmed/31181785 http://dx.doi.org/10.3390/medicina55060257 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mozaffari, Hamid Reza
Molavi, Maryam
Lopez-Jornet, Pia
Sadeghi, Masoud
Safaei, Mohsen
Imani, Mohammad Moslem
Sharifi, Roohollah
Moradpoor, Hedaiat
Golshah, Amin
Jamshidy, Ladan
Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
title Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
title_full Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
title_fullStr Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
title_full_unstemmed Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
title_short Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis
title_sort salivary and serum interferon-gamma/interleukin-4 ratio in oral lichen planus patients: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630336/
https://www.ncbi.nlm.nih.gov/pubmed/31181785
http://dx.doi.org/10.3390/medicina55060257
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