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Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630340/ https://www.ncbi.nlm.nih.gov/pubmed/31226738 http://dx.doi.org/10.3390/molecules24122287 |
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author | Paula, Pérez-Corredor Angelica Maria, Sabogal-Guáqueta Luis, Carrillo-Hormaza Gloria Patricia, Cardona-Gómez |
author_facet | Paula, Pérez-Corredor Angelica Maria, Sabogal-Guáqueta Luis, Carrillo-Hormaza Gloria Patricia, Cardona-Gómez |
author_sort | Paula, Pérez-Corredor |
collection | PubMed |
description | Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer’s disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD. |
format | Online Article Text |
id | pubmed-6630340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66303402019-08-19 Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model Paula, Pérez-Corredor Angelica Maria, Sabogal-Guáqueta Luis, Carrillo-Hormaza Gloria Patricia, Cardona-Gómez Molecules Article Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer’s disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD. MDPI 2019-06-20 /pmc/articles/PMC6630340/ /pubmed/31226738 http://dx.doi.org/10.3390/molecules24122287 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Paula, Pérez-Corredor Angelica Maria, Sabogal-Guáqueta Luis, Carrillo-Hormaza Gloria Patricia, Cardona-Gómez Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model |
title | Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model |
title_full | Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model |
title_fullStr | Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model |
title_full_unstemmed | Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model |
title_short | Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model |
title_sort | preventive effect of quercetin in a triple transgenic alzheimer’s disease mice model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630340/ https://www.ncbi.nlm.nih.gov/pubmed/31226738 http://dx.doi.org/10.3390/molecules24122287 |
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