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Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model

Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable...

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Autores principales: Paula, Pérez-Corredor, Angelica Maria, Sabogal-Guáqueta, Luis, Carrillo-Hormaza, Gloria Patricia, Cardona-Gómez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630340/
https://www.ncbi.nlm.nih.gov/pubmed/31226738
http://dx.doi.org/10.3390/molecules24122287
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author Paula, Pérez-Corredor
Angelica Maria, Sabogal-Guáqueta
Luis, Carrillo-Hormaza
Gloria Patricia, Cardona-Gómez
author_facet Paula, Pérez-Corredor
Angelica Maria, Sabogal-Guáqueta
Luis, Carrillo-Hormaza
Gloria Patricia, Cardona-Gómez
author_sort Paula, Pérez-Corredor
collection PubMed
description Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer’s disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD.
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spelling pubmed-66303402019-08-19 Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model Paula, Pérez-Corredor Angelica Maria, Sabogal-Guáqueta Luis, Carrillo-Hormaza Gloria Patricia, Cardona-Gómez Molecules Article Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer’s disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD. MDPI 2019-06-20 /pmc/articles/PMC6630340/ /pubmed/31226738 http://dx.doi.org/10.3390/molecules24122287 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paula, Pérez-Corredor
Angelica Maria, Sabogal-Guáqueta
Luis, Carrillo-Hormaza
Gloria Patricia, Cardona-Gómez
Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
title Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
title_full Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
title_fullStr Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
title_full_unstemmed Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
title_short Preventive Effect of Quercetin in a Triple Transgenic Alzheimer’s Disease Mice Model
title_sort preventive effect of quercetin in a triple transgenic alzheimer’s disease mice model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630340/
https://www.ncbi.nlm.nih.gov/pubmed/31226738
http://dx.doi.org/10.3390/molecules24122287
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