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Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes

In this study, a highly-ordered TiO(2) nanotube array was successfully fabricated on the surface of a pure titanium foil using the anodization method, and a hydroxyapatite (HA) layer was electrochemically deposited on the vertically aligned titania (TiO(2)) nanotube array. The TiO(2) nanotubes exhib...

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Autores principales: Zhang, Xiaokai, Zhang, Dechuang, Peng, Qing, Lin, Jianguo, Wen, Cuie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630346/
https://www.ncbi.nlm.nih.gov/pubmed/31226733
http://dx.doi.org/10.3390/ma12121979
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author Zhang, Xiaokai
Zhang, Dechuang
Peng, Qing
Lin, Jianguo
Wen, Cuie
author_facet Zhang, Xiaokai
Zhang, Dechuang
Peng, Qing
Lin, Jianguo
Wen, Cuie
author_sort Zhang, Xiaokai
collection PubMed
description In this study, a highly-ordered TiO(2) nanotube array was successfully fabricated on the surface of a pure titanium foil using the anodization method, and a hydroxyapatite (HA) layer was electrochemically deposited on the vertically aligned titania (TiO(2)) nanotube array. The TiO(2) nanotubes exhibited an inner diameter ranging from 44.5 to 136.8 nm, a wall thickness of 9.8 to 20 nm and a length of 1.25 to 3.94 µm, depending on the applied potential, and the anodization time and temperature. The TiO(2) nanotubes provided a high number of nucleation sites for the HA precipitation during electrochemical deposition, resulting in the formation of a nanoscale HA layer with a particle size of about 50 nm. The bond strength between the HA coating and the nanotubular layer with an inner diameter of 136.8 nm was over 28.7 MPa, and the interlocking between the nanoscale HA and the TiO(2) nanotubes may have been responsible for the high bond strength. The biocompatibility assessment was conducted on Ti foil with a composite coat of nanoscale HA and the TiO(2) nanotube array by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) array with mesenchymal stem cells (MSCs). The mesenchymal stem cells adhered to and spread onto the nanoscale HA layer with plenty of extending filopodia, indicating excellent biocompatibility of the HA coat, the composite coat of nanoscale HA and the TiO(2) nanotube array. The findings suggest that the nanoscale HA coating on the TiO(2) nanotube array might be a promising way to improve the bond strength and the compatibility of the HA layer.
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spelling pubmed-66303462019-08-19 Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes Zhang, Xiaokai Zhang, Dechuang Peng, Qing Lin, Jianguo Wen, Cuie Materials (Basel) Article In this study, a highly-ordered TiO(2) nanotube array was successfully fabricated on the surface of a pure titanium foil using the anodization method, and a hydroxyapatite (HA) layer was electrochemically deposited on the vertically aligned titania (TiO(2)) nanotube array. The TiO(2) nanotubes exhibited an inner diameter ranging from 44.5 to 136.8 nm, a wall thickness of 9.8 to 20 nm and a length of 1.25 to 3.94 µm, depending on the applied potential, and the anodization time and temperature. The TiO(2) nanotubes provided a high number of nucleation sites for the HA precipitation during electrochemical deposition, resulting in the formation of a nanoscale HA layer with a particle size of about 50 nm. The bond strength between the HA coating and the nanotubular layer with an inner diameter of 136.8 nm was over 28.7 MPa, and the interlocking between the nanoscale HA and the TiO(2) nanotubes may have been responsible for the high bond strength. The biocompatibility assessment was conducted on Ti foil with a composite coat of nanoscale HA and the TiO(2) nanotube array by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) array with mesenchymal stem cells (MSCs). The mesenchymal stem cells adhered to and spread onto the nanoscale HA layer with plenty of extending filopodia, indicating excellent biocompatibility of the HA coat, the composite coat of nanoscale HA and the TiO(2) nanotube array. The findings suggest that the nanoscale HA coating on the TiO(2) nanotube array might be a promising way to improve the bond strength and the compatibility of the HA layer. MDPI 2019-06-20 /pmc/articles/PMC6630346/ /pubmed/31226733 http://dx.doi.org/10.3390/ma12121979 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Xiaokai
Zhang, Dechuang
Peng, Qing
Lin, Jianguo
Wen, Cuie
Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes
title Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes
title_full Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes
title_fullStr Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes
title_full_unstemmed Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes
title_short Biocompatibility of Nanoscale Hydroxyapatite Coating on TiO(2) Nanotubes
title_sort biocompatibility of nanoscale hydroxyapatite coating on tio(2) nanotubes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630346/
https://www.ncbi.nlm.nih.gov/pubmed/31226733
http://dx.doi.org/10.3390/ma12121979
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