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Animal Models for Hepatitis E Virus

Hepatitis E virus (HEV) is an underdiagnosed pathogen with approximately 20 million infections each year and currently the most common cause of acute viral hepatitis. HEV was long considered to be confined to developing countries but there is increasing evidence that it is also a medical problem in...

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Autores principales: Corneillie, Laura, Banda, Dominic H., Meuleman, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630473/
https://www.ncbi.nlm.nih.gov/pubmed/31216711
http://dx.doi.org/10.3390/v11060564
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author Corneillie, Laura
Banda, Dominic H.
Meuleman, Philip
author_facet Corneillie, Laura
Banda, Dominic H.
Meuleman, Philip
author_sort Corneillie, Laura
collection PubMed
description Hepatitis E virus (HEV) is an underdiagnosed pathogen with approximately 20 million infections each year and currently the most common cause of acute viral hepatitis. HEV was long considered to be confined to developing countries but there is increasing evidence that it is also a medical problem in the Western world. HEV that infects humans belongs to the Orthohepevirus A species of the Hepeviridae family. Novel HEV-like viruses have been observed in a variety of animals and some have been shown to be able to cross the species barrier, causing infection in humans. Several cell culture models for HEV have been established in the past years, but their efficiency is usually relatively low. With the circulation of this virus and related viruses in a variety of species, several different animal models have been developed. In this review, we give an overview of these animal models, indicate their main characteristics, and highlight how they may contribute to our understanding of the basic aspects of the viral life cycle and cross-species infection, the study of pathogenesis, and the evaluation of novel preventative and therapeutic strategies.
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spelling pubmed-66304732019-08-19 Animal Models for Hepatitis E Virus Corneillie, Laura Banda, Dominic H. Meuleman, Philip Viruses Review Hepatitis E virus (HEV) is an underdiagnosed pathogen with approximately 20 million infections each year and currently the most common cause of acute viral hepatitis. HEV was long considered to be confined to developing countries but there is increasing evidence that it is also a medical problem in the Western world. HEV that infects humans belongs to the Orthohepevirus A species of the Hepeviridae family. Novel HEV-like viruses have been observed in a variety of animals and some have been shown to be able to cross the species barrier, causing infection in humans. Several cell culture models for HEV have been established in the past years, but their efficiency is usually relatively low. With the circulation of this virus and related viruses in a variety of species, several different animal models have been developed. In this review, we give an overview of these animal models, indicate their main characteristics, and highlight how they may contribute to our understanding of the basic aspects of the viral life cycle and cross-species infection, the study of pathogenesis, and the evaluation of novel preventative and therapeutic strategies. MDPI 2019-06-18 /pmc/articles/PMC6630473/ /pubmed/31216711 http://dx.doi.org/10.3390/v11060564 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Corneillie, Laura
Banda, Dominic H.
Meuleman, Philip
Animal Models for Hepatitis E Virus
title Animal Models for Hepatitis E Virus
title_full Animal Models for Hepatitis E Virus
title_fullStr Animal Models for Hepatitis E Virus
title_full_unstemmed Animal Models for Hepatitis E Virus
title_short Animal Models for Hepatitis E Virus
title_sort animal models for hepatitis e virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630473/
https://www.ncbi.nlm.nih.gov/pubmed/31216711
http://dx.doi.org/10.3390/v11060564
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