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Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach

The bioavailability of ophthalmic therapeutics is reduced because of the presence of physiological barriers whose primary function is to hinder the entry of exogenous agents, therefore also decreasing the bioavailability of locally administered drugs. Consequently, repeated ocular administrations ar...

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Detalles Bibliográficos
Autores principales: Sapino, Simona, Chirio, Daniela, Peira, Elena, Abellán Rubio, Elena, Brunella, Valentina, Jadhav, Sushilkumar A., Chindamo, Giulia, Gallarate, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630567/
https://www.ncbi.nlm.nih.gov/pubmed/31207951
http://dx.doi.org/10.3390/nano9060884
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author Sapino, Simona
Chirio, Daniela
Peira, Elena
Abellán Rubio, Elena
Brunella, Valentina
Jadhav, Sushilkumar A.
Chindamo, Giulia
Gallarate, Marina
author_facet Sapino, Simona
Chirio, Daniela
Peira, Elena
Abellán Rubio, Elena
Brunella, Valentina
Jadhav, Sushilkumar A.
Chindamo, Giulia
Gallarate, Marina
author_sort Sapino, Simona
collection PubMed
description The bioavailability of ophthalmic therapeutics is reduced because of the presence of physiological barriers whose primary function is to hinder the entry of exogenous agents, therefore also decreasing the bioavailability of locally administered drugs. Consequently, repeated ocular administrations are required. Hence, the development of drug delivery systems that ensure suitable drug concentration for prolonged times in different ocular tissues is certainly of great importance. This objective can be partially achieved using thermosensitive drug delivery systems that, owing to their ability of changing their state in response to temperature variations, from room to body temperature, may increase drug bioavailability. In the case of topical instillation, in situ forming gels increase pre-corneal drug residence time as a consequence of their enhanced adhesion to the corneal surface. Otherwise, in the case of intraocular and periocular, i.e., subconjunctival, retrobulbar, peribulbar administration, among others, they have the undoubted advantage of being easily injectable and, owing to their sudden thickening at body temperature, have the ability to form an in situ drug reservoir. As a result, the frequency of administration can be reduced, also favoring the patient’s adhesion to therapy. In the main section of this review, we discuss some of the most common treatment options for ocular diseases, with a special focus on posterior segment treatments, and summarize the most recent improvement deriving from thermosensitive drug delivery strategies. Aside from this, an additional section describes the most widespread in vitro models employed to evaluate the functionality of novel ophthalmic drug delivery systems.
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spelling pubmed-66305672019-08-19 Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach Sapino, Simona Chirio, Daniela Peira, Elena Abellán Rubio, Elena Brunella, Valentina Jadhav, Sushilkumar A. Chindamo, Giulia Gallarate, Marina Nanomaterials (Basel) Review The bioavailability of ophthalmic therapeutics is reduced because of the presence of physiological barriers whose primary function is to hinder the entry of exogenous agents, therefore also decreasing the bioavailability of locally administered drugs. Consequently, repeated ocular administrations are required. Hence, the development of drug delivery systems that ensure suitable drug concentration for prolonged times in different ocular tissues is certainly of great importance. This objective can be partially achieved using thermosensitive drug delivery systems that, owing to their ability of changing their state in response to temperature variations, from room to body temperature, may increase drug bioavailability. In the case of topical instillation, in situ forming gels increase pre-corneal drug residence time as a consequence of their enhanced adhesion to the corneal surface. Otherwise, in the case of intraocular and periocular, i.e., subconjunctival, retrobulbar, peribulbar administration, among others, they have the undoubted advantage of being easily injectable and, owing to their sudden thickening at body temperature, have the ability to form an in situ drug reservoir. As a result, the frequency of administration can be reduced, also favoring the patient’s adhesion to therapy. In the main section of this review, we discuss some of the most common treatment options for ocular diseases, with a special focus on posterior segment treatments, and summarize the most recent improvement deriving from thermosensitive drug delivery strategies. Aside from this, an additional section describes the most widespread in vitro models employed to evaluate the functionality of novel ophthalmic drug delivery systems. MDPI 2019-06-14 /pmc/articles/PMC6630567/ /pubmed/31207951 http://dx.doi.org/10.3390/nano9060884 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sapino, Simona
Chirio, Daniela
Peira, Elena
Abellán Rubio, Elena
Brunella, Valentina
Jadhav, Sushilkumar A.
Chindamo, Giulia
Gallarate, Marina
Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
title Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
title_full Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
title_fullStr Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
title_full_unstemmed Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
title_short Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
title_sort ocular drug delivery: a special focus on the thermosensitive approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630567/
https://www.ncbi.nlm.nih.gov/pubmed/31207951
http://dx.doi.org/10.3390/nano9060884
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