Cargando…

Cytolytic Perforin as an Adjuvant to Enhance the Immunogenicity of DNA Vaccines

DNA vaccines present one of the most cost-effective platforms to develop global vaccines, which have been tested for nearly three decades in preclinical and clinical settings with some success in the clinic. However, one of the major challenges for the development of DNA vaccines is their poor immun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shrestha, Ashish C., Wijesundara, Danushka K., Masavuli, Makutiro G., Mekonnen, Zelalem A., Gowans, Eric J., Grubor-Bauk, Branka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630607/ https://www.ncbi.nlm.nih.gov/pubmed/31052178 http://dx.doi.org/10.3390/vaccines7020038

Ejemplares similares

Safety Profile of a Multi-Antigenic DNA Vaccine Against Hepatitis C Virus
por: Gummow, Jason, et al.
Publicado: (2020)

Preclinical Development and Production of Virus-Like Particles As Vaccine Candidates for Hepatitis C
por: Masavuli, Makutiro Ghislain, et al.
Publicado: (2017)

Toward DNA-Based T-Cell Mediated Vaccines to Target HIV-1 and Hepatitis C Virus: Approaches to Elicit Localized Immunity for Protection
por: Mekonnen, Zelalem A., et al.
Publicado: (2019)

A Hepatitis C Virus DNA Vaccine Encoding a Secreted, Oligomerized Form of Envelope Proteins Is Highly Immunogenic and Elicits Neutralizing Antibodies in Vaccinated Mice
por: Masavuli, Makutiro Ghislain, et al.
Publicado: (2019)

Cytolytic DNA vaccine encoding lytic perforin augments the maturation of- and antigen presentation by- dendritic cells in a time-dependent manner
por: Wijesundara, Danushka K., et al.
Publicado: (2017)

Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine
por: Wijesundara, Danushka K., et al.
Publicado: (2023)

Emerging Targets for Developing T Cell-Mediated Vaccines for Human Immunodeficiency Virus (HIV)-1
por: Wijesundara, Danushka K., et al.
Publicado: (2017)

Enhanced T Cell Responses Induced by a Necrotic Dendritic Cell Vaccine, Expressing HCV NS3
por: Mekonnen, Zelalem A., et al.
Publicado: (2020)

A HIV-Tat/C4-binding protein chimera encoded by a DNA vaccine is highly immunogenic and contains acute EcoHIV infection in mice
por: Tomusange, Khamis, et al.
Publicado: (2016)

Mucosal vaccination with a live recombinant rhinovirus followed by intradermal DNA administration elicits potent and protective HIV-specific immune responses
por: Tomusange, Khamis, et al.
Publicado: (2016)

Increase in DNA vaccine efficacy by virosome delivery and co-expression of a cytolytic protein
por: Gargett, Tessa, et al.
Publicado: (2014)

Hepatitis C virus drives the pathogenesis of hepatocellular carcinoma: from immune evasion to carcinogenesis
por: Canavese, Miriam, et al.
Publicado: (2016)

Immunological Memory in Imiquimod-Induced Murine Model of Psoriasiform Dermatitis
por: Fenix, Kevin, et al.
Publicado: (2020)

Benzenesulphonamide inhibitors of the cytolytic protein perforin
por: Spicer, Julie A., et al.
Publicado: (2017)

NS1 DNA vaccination protects against Zika infection through T cell–mediated immunity in immunocompetent mice
por: Grubor-Bauk, B., et al.
Publicado: (2019)

Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth
por: Semple, Patricia L., et al.
Publicado: (2011)

A calcium- and perforin-independent pathway of killing mediated by murine cytolytic lymphocytes
Publicado: (1987)

Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery
por: Christiansen, D., et al.
Publicado: (2019)

Impact of Pre-Existing Immunity to Influenza on Live-Attenuated Influenza Vaccine (LAIV) Immunogenicity
por: Roy, Sreeja, et al.
Publicado: (2020)

Resistance of cytolytic lymphocytes to perforin-mediated killing. Induction of resistance correlates with increase in cytotoxicity
Publicado: (1989)

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
por: Ryan, Feargal J., et al.
Publicado: (2022)

Resistance of cytolytic lymphocytes to perforin-mediated killing. Lack of correlation with complement-associated homologous species restriction
Publicado: (1988)

Exploration of a Series of 5-Arylidene-2-thioxoimidazolidin-4-ones as Inhibitors of the Cytolytic Protein Perforin
por: Spicer, Julie A., et al.
Publicado: (2013)

SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents
por: Garcia-Valtanen, Pablo, et al.
Publicado: (2022)

LUNG group 2 innate lymphoid cells as a new adjuvant target to enhance intranasal vaccine efficacy against influenza
por: Williams, Clare M, et al.
Publicado: (2022)

Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines
por: Isaacs, Ariel, et al.
Publicado: (2021)

The pore-forming protein (perforin) of cytolytic T lymphocytes is immunologically related to the components of membrane attack complex of complement through cysteine-rich domains
Publicado: (1986)

Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19
por: Perkins, Griffith B., et al.
Publicado: (2022)

Unraveling the Convoluted Biological Roles of Type I Interferons in Infection and Immunity: A Way Forward for Therapeutics and Vaccine Design
por: Wijesundara, Danushka Kumara, et al.
Publicado: (2014)

Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene
Publicado: (1993)

Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)—rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-CoV-2 vaccine response in kidney transplant recipients
por: Tunbridge, Matthew, et al.
Publicado: (2022)

Perforin and hematological cancer
por: Covas, Dimas Tadeu
Publicado: (2011)

A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines
por: Ryan, Feargal J., et al.
Publicado: (2023)

Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine
por: Christiansen, D., et al.
Publicado: (2018)

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
por: Arapović, Maja, et al.
Publicado: (2016)

Purified perforin induces target cell lysis but not DNA fragmentation
Publicado: (1989)

Determination of quantitative and site-specific DNA methylation of perforin by pyrosequencing
por: Narasimhan, Supraja, et al.
Publicado: (2009)

Immunogenicity and Safety of Beta-Adjuvanted Recombinant Booster Vaccine
por: Launay, Odile, et al.
Publicado: (2022)

Impact of Pre-Existing Immunity on Live Attenuated Influenza Vaccine-Induced Cross-Protective Immunity
por: Roy, Sreeja, et al.
Publicado: (2020)

Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_3c5jlc4cfi8ujs8ogt10fpvbr1