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Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers

For the preparation of thermoresponsive copolymers, for e.g., tissue engineering scaffolds or drug carriers, a precise control of the synthesis parameters to set the lower critical solution temperature (LCST) is required. However, the correlations between molecular parameters and LCST are partially...

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Autores principales: García-Peñas, Alberto, Biswas, Chandra Sekhar, Liang, Weijun, Wang, Yu, Yang, Pianpian, Stadler, Florian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630648/
https://www.ncbi.nlm.nih.gov/pubmed/31167423
http://dx.doi.org/10.3390/polym11060991
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author García-Peñas, Alberto
Biswas, Chandra Sekhar
Liang, Weijun
Wang, Yu
Yang, Pianpian
Stadler, Florian J.
author_facet García-Peñas, Alberto
Biswas, Chandra Sekhar
Liang, Weijun
Wang, Yu
Yang, Pianpian
Stadler, Florian J.
author_sort García-Peñas, Alberto
collection PubMed
description For the preparation of thermoresponsive copolymers, for e.g., tissue engineering scaffolds or drug carriers, a precise control of the synthesis parameters to set the lower critical solution temperature (LCST) is required. However, the correlations between molecular parameters and LCST are partially unknown and, furthermore, LCST is defined as an exact temperature, which oversimplifies the real situation. Here, random N-isopropylacrylamide (NIPAM)/dopamine methacrylamide (DMA) copolymers were prepared under a systematical variation of molecular weight and comonomer amount and their LCST in water studied by calorimetry, turbidimetry, and rheology. Structural information was deduced from observed transitions clarifying the contributions of molecular weight, comonomer content, end-group effect or polymerization degree on LCST, which were then statistically modeled. This proved that the LCST can be predicted through molecular structure and conditions of the solutions. While the hydrophobic DMA lowers the LCST especially the onset, polymerization degree has an important but smaller influence over all the whole LCST range.
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spelling pubmed-66306482019-08-19 Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers García-Peñas, Alberto Biswas, Chandra Sekhar Liang, Weijun Wang, Yu Yang, Pianpian Stadler, Florian J. Polymers (Basel) Article For the preparation of thermoresponsive copolymers, for e.g., tissue engineering scaffolds or drug carriers, a precise control of the synthesis parameters to set the lower critical solution temperature (LCST) is required. However, the correlations between molecular parameters and LCST are partially unknown and, furthermore, LCST is defined as an exact temperature, which oversimplifies the real situation. Here, random N-isopropylacrylamide (NIPAM)/dopamine methacrylamide (DMA) copolymers were prepared under a systematical variation of molecular weight and comonomer amount and their LCST in water studied by calorimetry, turbidimetry, and rheology. Structural information was deduced from observed transitions clarifying the contributions of molecular weight, comonomer content, end-group effect or polymerization degree on LCST, which were then statistically modeled. This proved that the LCST can be predicted through molecular structure and conditions of the solutions. While the hydrophobic DMA lowers the LCST especially the onset, polymerization degree has an important but smaller influence over all the whole LCST range. MDPI 2019-06-04 /pmc/articles/PMC6630648/ /pubmed/31167423 http://dx.doi.org/10.3390/polym11060991 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-Peñas, Alberto
Biswas, Chandra Sekhar
Liang, Weijun
Wang, Yu
Yang, Pianpian
Stadler, Florian J.
Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
title Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
title_full Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
title_fullStr Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
title_full_unstemmed Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
title_short Effect of Hydrophobic Interactions on Lower Critical Solution Temperature for Poly(N-isopropylacrylamide-co-dopamine Methacrylamide) Copolymers
title_sort effect of hydrophobic interactions on lower critical solution temperature for poly(n-isopropylacrylamide-co-dopamine methacrylamide) copolymers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630648/
https://www.ncbi.nlm.nih.gov/pubmed/31167423
http://dx.doi.org/10.3390/polym11060991
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