Novel Population Pharmacokinetic Approach to Explain the Differences between Cystic Fibrosis Patients and Healthy Volunteers via Protein Binding

The pharmacokinetics in patients with cystic fibrosis (CF) has long been thought to differ considerably from that in healthy volunteers. For highly protein bound β-lactams, profound pharmacokinetic differences were observed between comparatively morbid patients with CF and healthy volunteers. These...

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Detalles Bibliográficos
Autores principales: Shah, Nirav R., Bulitta, Jürgen B., Kinzig, Martina, Landersdorfer, Cornelia B., Jiao, Yuanyuan, Sutaria, Dhruvitkumar S., Tao, Xun, Höhl, Rainer, Holzgrabe, Ulrike, Kees, Frieder, Stephan, Ulrich, Sörgel, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630667/
https://www.ncbi.nlm.nih.gov/pubmed/31216743
http://dx.doi.org/10.3390/pharmaceutics11060286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630667/
https://www.ncbi.nlm.nih.gov/pubmed/31216743
http://dx.doi.org/10.3390/pharmaceutics11060286

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