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Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery

Cryosurgery used on patients with unresectable pancreatic cancer improved their quality of life, but mainly because of the pain relief. In postoperative patients, multifaceted changes in immunity were found, and the state of the immune system prior to surgery often was a decisive factor to indicate...

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Autores principales: Zemskov, Vladimir M., Pronko, Konstantin N., Ionkin, Dmitrii A., Chzhao, Alexei V., Kozlova, Maria N., Barsukov, Alexander A., Shishkina, Nadezhda S., Demidova, Valentina S., Zemskov, Andrei M., Revishvili, Amiran Sh.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630675/
https://www.ncbi.nlm.nih.gov/pubmed/31234504
http://dx.doi.org/10.3390/medsci7060073
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author Zemskov, Vladimir M.
Pronko, Konstantin N.
Ionkin, Dmitrii A.
Chzhao, Alexei V.
Kozlova, Maria N.
Barsukov, Alexander A.
Shishkina, Nadezhda S.
Demidova, Valentina S.
Zemskov, Andrei M.
Revishvili, Amiran Sh.
author_facet Zemskov, Vladimir M.
Pronko, Konstantin N.
Ionkin, Dmitrii A.
Chzhao, Alexei V.
Kozlova, Maria N.
Barsukov, Alexander A.
Shishkina, Nadezhda S.
Demidova, Valentina S.
Zemskov, Andrei M.
Revishvili, Amiran Sh.
author_sort Zemskov, Vladimir M.
collection PubMed
description Cryosurgery used on patients with unresectable pancreatic cancer improved their quality of life, but mainly because of the pain relief. In postoperative patients, multifaceted changes in immunity were found, and the state of the immune system prior to surgery often was a decisive factor to indicate whether further disorders in the postoperative period would develop, or by contrast, it would boost its recovery. Some patients receiving cryosurgery showed immune system imbalance and activation, and of antitumor immunity in particular. It has been suggested that the advisability of immunotropic therapy for specific treatment algorithms should be predicted or the therapy should be suspended at some pathologic stage, and this has been immunologically confirmed. Cryosurgery should be considered as a reasonable alternative to the existing types of surgery for pancreatic cancer or as an essential component of multimodal therapy, consisting of topical cryosurgery, chemotherapy, and immunotropic therapy, to boost antitumor immunity and to discontinue cytoreductive therapy due to its toxic effects.
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spelling pubmed-66306752019-08-19 Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery Zemskov, Vladimir M. Pronko, Konstantin N. Ionkin, Dmitrii A. Chzhao, Alexei V. Kozlova, Maria N. Barsukov, Alexander A. Shishkina, Nadezhda S. Demidova, Valentina S. Zemskov, Andrei M. Revishvili, Amiran Sh. Med Sci (Basel) Article Cryosurgery used on patients with unresectable pancreatic cancer improved their quality of life, but mainly because of the pain relief. In postoperative patients, multifaceted changes in immunity were found, and the state of the immune system prior to surgery often was a decisive factor to indicate whether further disorders in the postoperative period would develop, or by contrast, it would boost its recovery. Some patients receiving cryosurgery showed immune system imbalance and activation, and of antitumor immunity in particular. It has been suggested that the advisability of immunotropic therapy for specific treatment algorithms should be predicted or the therapy should be suspended at some pathologic stage, and this has been immunologically confirmed. Cryosurgery should be considered as a reasonable alternative to the existing types of surgery for pancreatic cancer or as an essential component of multimodal therapy, consisting of topical cryosurgery, chemotherapy, and immunotropic therapy, to boost antitumor immunity and to discontinue cytoreductive therapy due to its toxic effects. MDPI 2019-06-22 /pmc/articles/PMC6630675/ /pubmed/31234504 http://dx.doi.org/10.3390/medsci7060073 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zemskov, Vladimir M.
Pronko, Konstantin N.
Ionkin, Dmitrii A.
Chzhao, Alexei V.
Kozlova, Maria N.
Barsukov, Alexander A.
Shishkina, Nadezhda S.
Demidova, Valentina S.
Zemskov, Andrei M.
Revishvili, Amiran Sh.
Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery
title Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery
title_full Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery
title_fullStr Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery
title_full_unstemmed Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery
title_short Immune Status of Pancreatic Cancer Patients Receiving Cryosurgery
title_sort immune status of pancreatic cancer patients receiving cryosurgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630675/
https://www.ncbi.nlm.nih.gov/pubmed/31234504
http://dx.doi.org/10.3390/medsci7060073
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