Hepatitis E Virus Infections among Patients with Acute Febrile Jaundice in Burkina Faso

Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained marker...

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Detalles Bibliográficos
Autores principales: Dimeglio, Chloé, Kania, Dramane, Mantono, Judith Mbombi, Kagoné, Thérèse, Zida, Sylvie, Tassembedo, Souleymane, Dicko, Amadou, Tinto, Bachirou, Yaro, Seydou, Hien, Hervé, Rouamba, Jérémi, Bicaba, Brice, Medah, Isaïe, Meda, Nicolas, Traoré, Oumar, Tuaillon, Edouard, Abravanel, Florence, Izopet, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630816/
https://www.ncbi.nlm.nih.gov/pubmed/31207982
http://dx.doi.org/10.3390/v11060554
Descripción
Sumario:Hepatitis E virus infection is a significant public health problem in many parts of the world including Africa. We tested serum samples from 900 patients in Burkina Faso presenting with febrile icterus. They all tested negative for yellow fever, but those from 23/900 (2.6%) patients contained markers of acute HEV infection (anti-HEV IgM and HEV RNA positive). Genotyping indicated that 14 of the strains were HEV genotype 2b. There was an overall HEV IgG seroprevalence of 18.2% (164/900). In a bivariate analysis, the factors linked to HEV exposure were climate and patient age. Older patients and those living in arid regions were more likely to have HEV infection. HEV genotype 2b circulating only in humans can be involved in some acute febrile icterus cases in Burkina Faso. Better access to safe water, sanitation, and improved personal hygiene should improve control of HEV infection in this country.

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