Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

The goal of this study was to investigate the potential for a cannabidiol-rich cannabis extract (CRCE) to interact with the most common over-the-counter drug and the major known cause of drug-induced liver injury–acetaminophen (APAP)–in aged female CD-1 mice. Gavaging mice with 116 mg/kg of cannabid...

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Detalles Bibliográficos
Autores principales: Ewing, Laura E., McGill, Mitchell R., Yee, Eric U., Quick, Charles M., Skinner, Charles M., Kennon-McGill, Stefanie, Clemens, Melissa, Vazquez, Joel H., McCullough, Sandra S., Williams, D. Keith, Kutanzi, Kristy R., Walker, Larry A., ElSohly, Mahmoud A., James, Laura P., Gurley, Bill J., Koturbash, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630875/
https://www.ncbi.nlm.nih.gov/pubmed/31212965
http://dx.doi.org/10.3390/molecules24122256

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