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Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials

Biomaterials should be bioactive in stimulating the surrounding tissue to accelerate the ingrowth of permanent implants. Chemical and topographical features of the biomaterial surface affect cell physiology at the interface. A frequently asked question is whether the chemistry or the topography domi...

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Autores principales: Nebe, J. Barbara, Rebl, Henrike, Schlosser, Michael, Staehlke, Susanne, Gruening, Martina, Weltmann, Klaus-Dieter, Walschus, Uwe, Finke, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631006/
https://www.ncbi.nlm.nih.gov/pubmed/31195717
http://dx.doi.org/10.3390/polym11061004
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author Nebe, J. Barbara
Rebl, Henrike
Schlosser, Michael
Staehlke, Susanne
Gruening, Martina
Weltmann, Klaus-Dieter
Walschus, Uwe
Finke, Birgit
author_facet Nebe, J. Barbara
Rebl, Henrike
Schlosser, Michael
Staehlke, Susanne
Gruening, Martina
Weltmann, Klaus-Dieter
Walschus, Uwe
Finke, Birgit
author_sort Nebe, J. Barbara
collection PubMed
description Biomaterials should be bioactive in stimulating the surrounding tissue to accelerate the ingrowth of permanent implants. Chemical and topographical features of the biomaterial surface affect cell physiology at the interface. A frequently asked question is whether the chemistry or the topography dominates the cell-material interaction. Recently, we demonstrated that a plasma-chemical modification using allylamine as a precursor was able to boost not only cell attachment and cell migration, but also intracellular signaling in vital cells. This microwave plasma process generated a homogenous nanolayer with randomly distributed, positively charged amino groups. In contrast, the surface of the human osteoblast is negatively charged at −15 mV due to its hyaluronan coat. As a consequence, we assumed that positive charges at the material surface—provoking electrostatic interaction forces—are attractive for the first cell encounter. This plasma-chemical nanocoating can be used for several biomaterials in orthopedic and dental implantology like titanium, titanium alloys, calcium phosphate scaffolds, and polylactide fiber meshes produced by electrospinning. In this regard, we wanted to ascertain whether plasma polymerized allylamine (PPAAm) is also suitable for increasing the attractiveness of a ceramic surface for dental implants using Yttria-stabilized tetragonal zirconia.
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spelling pubmed-66310062019-08-19 Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials Nebe, J. Barbara Rebl, Henrike Schlosser, Michael Staehlke, Susanne Gruening, Martina Weltmann, Klaus-Dieter Walschus, Uwe Finke, Birgit Polymers (Basel) Article Biomaterials should be bioactive in stimulating the surrounding tissue to accelerate the ingrowth of permanent implants. Chemical and topographical features of the biomaterial surface affect cell physiology at the interface. A frequently asked question is whether the chemistry or the topography dominates the cell-material interaction. Recently, we demonstrated that a plasma-chemical modification using allylamine as a precursor was able to boost not only cell attachment and cell migration, but also intracellular signaling in vital cells. This microwave plasma process generated a homogenous nanolayer with randomly distributed, positively charged amino groups. In contrast, the surface of the human osteoblast is negatively charged at −15 mV due to its hyaluronan coat. As a consequence, we assumed that positive charges at the material surface—provoking electrostatic interaction forces—are attractive for the first cell encounter. This plasma-chemical nanocoating can be used for several biomaterials in orthopedic and dental implantology like titanium, titanium alloys, calcium phosphate scaffolds, and polylactide fiber meshes produced by electrospinning. In this regard, we wanted to ascertain whether plasma polymerized allylamine (PPAAm) is also suitable for increasing the attractiveness of a ceramic surface for dental implants using Yttria-stabilized tetragonal zirconia. MDPI 2019-06-05 /pmc/articles/PMC6631006/ /pubmed/31195717 http://dx.doi.org/10.3390/polym11061004 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nebe, J. Barbara
Rebl, Henrike
Schlosser, Michael
Staehlke, Susanne
Gruening, Martina
Weltmann, Klaus-Dieter
Walschus, Uwe
Finke, Birgit
Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials
title Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials
title_full Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials
title_fullStr Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials
title_full_unstemmed Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials
title_short Plasma Polymerized Allylamine—The Unique Cell-Attractive Nanolayer for Dental Implant Materials
title_sort plasma polymerized allylamine—the unique cell-attractive nanolayer for dental implant materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631006/
https://www.ncbi.nlm.nih.gov/pubmed/31195717
http://dx.doi.org/10.3390/polym11061004
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