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Strategic Planning for Tuberculosis Control in the Republic of Fiji

The tuberculosis (TB) health burden in Fiji has been declining in recent years, although challenges remain in improving control of the diabetes co-epidemic and achieving adequate case detection across the widely dispersed archipelago. We applied a mathematical model of TB transmission to the TB epid...

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Autores principales: Ragonnet, Romain, Underwood, Frank, Doan, Tan, Rafai, Eric, Trauer, James, McBryde, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631049/
https://www.ncbi.nlm.nih.gov/pubmed/31022901
http://dx.doi.org/10.3390/tropicalmed4020071
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author Ragonnet, Romain
Underwood, Frank
Doan, Tan
Rafai, Eric
Trauer, James
McBryde, Emma
author_facet Ragonnet, Romain
Underwood, Frank
Doan, Tan
Rafai, Eric
Trauer, James
McBryde, Emma
author_sort Ragonnet, Romain
collection PubMed
description The tuberculosis (TB) health burden in Fiji has been declining in recent years, although challenges remain in improving control of the diabetes co-epidemic and achieving adequate case detection across the widely dispersed archipelago. We applied a mathematical model of TB transmission to the TB epidemic in Fiji that captured the historical reality over several decades, including age stratification, diabetes, varying disease manifestations, and incorrect diagnoses. Next, we simulated six intervention scenarios that are under consideration by the Fiji National Tuberculosis Program. Our findings show that the interventions were able to achieve only modest improvements in disease burden, with awareness raising being the most effective intervention to reduce TB incidence, and treatment support yielding the highest impact on mortality. These improvements would fall far short of the ambitious targets that have been set by the country, and could easily be derailed by moderate increases in the diabetes burden. Furthermore, the effectiveness of the interventions was limited by the extensive pool of latent TB infection, because the programs were directed at only active cases, and thus were unlikely to achieve the desired reductions in burden. Therefore, it is essential to address the co-epidemic of diabetes and treat people with latent TB infection.
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spelling pubmed-66310492019-08-19 Strategic Planning for Tuberculosis Control in the Republic of Fiji Ragonnet, Romain Underwood, Frank Doan, Tan Rafai, Eric Trauer, James McBryde, Emma Trop Med Infect Dis Article The tuberculosis (TB) health burden in Fiji has been declining in recent years, although challenges remain in improving control of the diabetes co-epidemic and achieving adequate case detection across the widely dispersed archipelago. We applied a mathematical model of TB transmission to the TB epidemic in Fiji that captured the historical reality over several decades, including age stratification, diabetes, varying disease manifestations, and incorrect diagnoses. Next, we simulated six intervention scenarios that are under consideration by the Fiji National Tuberculosis Program. Our findings show that the interventions were able to achieve only modest improvements in disease burden, with awareness raising being the most effective intervention to reduce TB incidence, and treatment support yielding the highest impact on mortality. These improvements would fall far short of the ambitious targets that have been set by the country, and could easily be derailed by moderate increases in the diabetes burden. Furthermore, the effectiveness of the interventions was limited by the extensive pool of latent TB infection, because the programs were directed at only active cases, and thus were unlikely to achieve the desired reductions in burden. Therefore, it is essential to address the co-epidemic of diabetes and treat people with latent TB infection. MDPI 2019-04-24 /pmc/articles/PMC6631049/ /pubmed/31022901 http://dx.doi.org/10.3390/tropicalmed4020071 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ragonnet, Romain
Underwood, Frank
Doan, Tan
Rafai, Eric
Trauer, James
McBryde, Emma
Strategic Planning for Tuberculosis Control in the Republic of Fiji
title Strategic Planning for Tuberculosis Control in the Republic of Fiji
title_full Strategic Planning for Tuberculosis Control in the Republic of Fiji
title_fullStr Strategic Planning for Tuberculosis Control in the Republic of Fiji
title_full_unstemmed Strategic Planning for Tuberculosis Control in the Republic of Fiji
title_short Strategic Planning for Tuberculosis Control in the Republic of Fiji
title_sort strategic planning for tuberculosis control in the republic of fiji
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631049/
https://www.ncbi.nlm.nih.gov/pubmed/31022901
http://dx.doi.org/10.3390/tropicalmed4020071
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