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Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients

Background and objectives: Non-melanoma skin cancers (NMSCs) represent the most frequently encountered malignancy in organ transplant recipients and their incidence increases proportionally to the duration of immunosuppression. Furthermore, patients of this group often develop multiple and more aggr...

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Autores principales: Zavattaro, Elisa, Fava, Paolo, Veronese, Federica, Cavaliere, Giovanni, Ferrante, Daniela, Cantaluppi, Vincenzo, Ranghino, Andrea, Biancone, Luigi, Fierro, Maria Teresa, Savoia, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631054/
https://www.ncbi.nlm.nih.gov/pubmed/31208110
http://dx.doi.org/10.3390/medicina55060279
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author Zavattaro, Elisa
Fava, Paolo
Veronese, Federica
Cavaliere, Giovanni
Ferrante, Daniela
Cantaluppi, Vincenzo
Ranghino, Andrea
Biancone, Luigi
Fierro, Maria Teresa
Savoia, Paola
author_facet Zavattaro, Elisa
Fava, Paolo
Veronese, Federica
Cavaliere, Giovanni
Ferrante, Daniela
Cantaluppi, Vincenzo
Ranghino, Andrea
Biancone, Luigi
Fierro, Maria Teresa
Savoia, Paola
author_sort Zavattaro, Elisa
collection PubMed
description Background and objectives: Non-melanoma skin cancers (NMSCs) represent the most frequently encountered malignancy in organ transplant recipients and their incidence increases proportionally to the duration of immunosuppression. Furthermore, patients of this group often develop multiple and more aggressive cancers and, to date, risk factors for the development of multiple NMSCs have not been yet established. The present study aimed to identify risk factors for multiple NMSCs in a cohort of Italian kidney transplant recipients (KTRs). Materials and Methods: We consecutively included all KTRs referring to two post-transplant outpatient clinics of North-Western Italy between 2001 and 2017. In this cohort, we evaluated different clinical (endogenous and exogenous) risk factors in order to establish their correlation with NMSCs. Results: 518 KTRs were included, of which 148 (28.6%) developed keratinocyte cancers, with a single tumor in 77 subjects, two skin cancers in 31 patients, 3 in 21 patients, whereas at least 4 NMSCs developed in 19 KTRs. We observed an increased risk of the development of cutaneous neoplasms for the male gender, old age at transplantation (>50 years), light phototype, solar lentigo, history of sunburns, or chronic actinic damage. Considering patients affected by multiple keratinocyte neoplasms, we observed a significant association of actinic damage and solar lentigo with an increased risk of NMSCs; their significance was confirmed even at the multivariable model. Conclusions: Our results confirm the role played by chronic cutaneous actinic damage in carcinogenesis on KTRs and highlight the significance of individualized periodic dermatological screening.
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spelling pubmed-66310542019-08-19 Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients Zavattaro, Elisa Fava, Paolo Veronese, Federica Cavaliere, Giovanni Ferrante, Daniela Cantaluppi, Vincenzo Ranghino, Andrea Biancone, Luigi Fierro, Maria Teresa Savoia, Paola Medicina (Kaunas) Article Background and objectives: Non-melanoma skin cancers (NMSCs) represent the most frequently encountered malignancy in organ transplant recipients and their incidence increases proportionally to the duration of immunosuppression. Furthermore, patients of this group often develop multiple and more aggressive cancers and, to date, risk factors for the development of multiple NMSCs have not been yet established. The present study aimed to identify risk factors for multiple NMSCs in a cohort of Italian kidney transplant recipients (KTRs). Materials and Methods: We consecutively included all KTRs referring to two post-transplant outpatient clinics of North-Western Italy between 2001 and 2017. In this cohort, we evaluated different clinical (endogenous and exogenous) risk factors in order to establish their correlation with NMSCs. Results: 518 KTRs were included, of which 148 (28.6%) developed keratinocyte cancers, with a single tumor in 77 subjects, two skin cancers in 31 patients, 3 in 21 patients, whereas at least 4 NMSCs developed in 19 KTRs. We observed an increased risk of the development of cutaneous neoplasms for the male gender, old age at transplantation (>50 years), light phototype, solar lentigo, history of sunburns, or chronic actinic damage. Considering patients affected by multiple keratinocyte neoplasms, we observed a significant association of actinic damage and solar lentigo with an increased risk of NMSCs; their significance was confirmed even at the multivariable model. Conclusions: Our results confirm the role played by chronic cutaneous actinic damage in carcinogenesis on KTRs and highlight the significance of individualized periodic dermatological screening. MDPI 2019-06-16 /pmc/articles/PMC6631054/ /pubmed/31208110 http://dx.doi.org/10.3390/medicina55060279 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zavattaro, Elisa
Fava, Paolo
Veronese, Federica
Cavaliere, Giovanni
Ferrante, Daniela
Cantaluppi, Vincenzo
Ranghino, Andrea
Biancone, Luigi
Fierro, Maria Teresa
Savoia, Paola
Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients
title Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients
title_full Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients
title_fullStr Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients
title_full_unstemmed Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients
title_short Identification of Risk Factors for Multiple Non-Melanoma Skin Cancers in Italian Kidney Transplant Recipients
title_sort identification of risk factors for multiple non-melanoma skin cancers in italian kidney transplant recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631054/
https://www.ncbi.nlm.nih.gov/pubmed/31208110
http://dx.doi.org/10.3390/medicina55060279
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