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Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery

The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability. Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying trimethylaminehy...

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Autores principales: Benyerbah, Nassim, Ispas-Szabo, Pompilia, Sakeer, Khalil, Chapdelaine, Daniel, Mateescu, Mircea Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631206/
https://www.ncbi.nlm.nih.gov/pubmed/31159403
http://dx.doi.org/10.3390/pharmaceutics11060253
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author Benyerbah, Nassim
Ispas-Szabo, Pompilia
Sakeer, Khalil
Chapdelaine, Daniel
Mateescu, Mircea Alexandru
author_facet Benyerbah, Nassim
Ispas-Szabo, Pompilia
Sakeer, Khalil
Chapdelaine, Daniel
Mateescu, Mircea Alexandru
author_sort Benyerbah, Nassim
collection PubMed
description The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability. Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying trimethylaminehydroxypropyl (TMA) cationic groups and carboxymethyl (CM) anionic groups was obtained in one-step synthesis in aqueous media. Trimethylaminestarch (TMAS) and carboxymethylstarch (CMS) powders were also synthesized separately and then homogenized at equal proportions in liquid phase for co-processing by spray drying (SD) to obtain polyelectrolytic complexes TMAS-CMS (SD). Similarly, equal amounts of TMAS and CMS powders were dry mixed (DM) to obtain TMAS:CMS (DM). Monolithic tablets were obtained by direct compression of excipient/API mixes with 60% or 80% drug loads. The in vitro dissolution tests showed that ampholytic (TMACMS) and co-processed TMAS-CMS (SD) with selected tracers (one from each class of Biopharmaceutical Classification System (BCS)), were able to control the release even at very high loading (80%). The presence of opposite charges located at adequate distances may impact the polymeric chain organisation, their self-assembling, and implicitly the control of drug release. In conclusion, irrespective of preparation procedure, ampholytic and polyelectrolytic starch materials exhibited similar behaviours. Electrostatic interactions generated polymeric matrices conferring good mechanical features of tablets even at high drug loading.
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spelling pubmed-66312062019-08-19 Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery Benyerbah, Nassim Ispas-Szabo, Pompilia Sakeer, Khalil Chapdelaine, Daniel Mateescu, Mircea Alexandru Pharmaceutics Article The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability. Ampholytic trimethylaminecarboxymethylstarch (TMACMS) simultaneously carrying trimethylaminehydroxypropyl (TMA) cationic groups and carboxymethyl (CM) anionic groups was obtained in one-step synthesis in aqueous media. Trimethylaminestarch (TMAS) and carboxymethylstarch (CMS) powders were also synthesized separately and then homogenized at equal proportions in liquid phase for co-processing by spray drying (SD) to obtain polyelectrolytic complexes TMAS-CMS (SD). Similarly, equal amounts of TMAS and CMS powders were dry mixed (DM) to obtain TMAS:CMS (DM). Monolithic tablets were obtained by direct compression of excipient/API mixes with 60% or 80% drug loads. The in vitro dissolution tests showed that ampholytic (TMACMS) and co-processed TMAS-CMS (SD) with selected tracers (one from each class of Biopharmaceutical Classification System (BCS)), were able to control the release even at very high loading (80%). The presence of opposite charges located at adequate distances may impact the polymeric chain organisation, their self-assembling, and implicitly the control of drug release. In conclusion, irrespective of preparation procedure, ampholytic and polyelectrolytic starch materials exhibited similar behaviours. Electrostatic interactions generated polymeric matrices conferring good mechanical features of tablets even at high drug loading. MDPI 2019-06-01 /pmc/articles/PMC6631206/ /pubmed/31159403 http://dx.doi.org/10.3390/pharmaceutics11060253 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benyerbah, Nassim
Ispas-Szabo, Pompilia
Sakeer, Khalil
Chapdelaine, Daniel
Mateescu, Mircea Alexandru
Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
title Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
title_full Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
title_fullStr Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
title_full_unstemmed Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
title_short Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
title_sort ampholytic and polyelectrolytic starch as matrices for controlled drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631206/
https://www.ncbi.nlm.nih.gov/pubmed/31159403
http://dx.doi.org/10.3390/pharmaceutics11060253
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