Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

Down syndrome (DS) is a genetic disorder that causes cognitive impairment. The staggering effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology. We examined the neuron-astrocyte interplay in a fully recapitulated HSA21 trisom...

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Detalles Bibliográficos
Autores principales: Mizuno, Grace O., Wang, Yinxue, Shi, Guilai, Wang, Yizhi, Sun, Junqing, Papadopoulos, Stelios, Broussard, Gerard J., Unger, Elizabeth K., Deng, Wenbin, Weick, Jason, Bhattacharyya, Anita, Chen, Chao-Yin, Yu, Guoqiang, Looger, Loren L., Tian, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631348/
https://www.ncbi.nlm.nih.gov/pubmed/29996097
http://dx.doi.org/10.1016/j.celrep.2018.06.033

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