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Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report
Dengue is still an important cause of disease and mortality in tropical countries, as is influenza A virus, which is also a cause of epidemics all over the globe. In this article, we present the case of a 31-year-old woman who was in her second trimester of pregnancy and presented with severe dengue...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631397/ https://www.ncbi.nlm.nih.gov/pubmed/31117316 http://dx.doi.org/10.3390/tropicalmed4020084 |
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author | Guzmán-Rodríguez, Mónica Acosta-Ñañez, Héctor F. Mantilla, Julio César Bonelo, Anilza |
author_facet | Guzmán-Rodríguez, Mónica Acosta-Ñañez, Héctor F. Mantilla, Julio César Bonelo, Anilza |
author_sort | Guzmán-Rodríguez, Mónica |
collection | PubMed |
description | Dengue is still an important cause of disease and mortality in tropical countries, as is influenza A virus, which is also a cause of epidemics all over the globe. In this article, we present the case of a 31-year-old woman who was in her second trimester of pregnancy and presented with severe dengue with hematological and neurological complications, and premature labor. She was misdiagnosed with bacterial infection and received antibiotic treatment with no improvement of the clinical manifestations and previous to death, she was diagnosed with dengue infection. She died from cardiorespiratory arrest. In the postmortem evaluation, influenza A co-infection was confirmed and characterization of the tissue damage and immune response in lung, liver, kidney, heart, spleen, and brain was determined, finding a severe inflammatory response in lung with T cells and macrophages infiltrating the tissue. This case report highlights the risks of accepting a single diagnosis, especially in endemic countries to multiple tropical diseases, which can lead to delay in appropriate treatment that could reduce morbidity and mortality. |
format | Online Article Text |
id | pubmed-6631397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66313972019-08-19 Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report Guzmán-Rodríguez, Mónica Acosta-Ñañez, Héctor F. Mantilla, Julio César Bonelo, Anilza Trop Med Infect Dis Case Report Dengue is still an important cause of disease and mortality in tropical countries, as is influenza A virus, which is also a cause of epidemics all over the globe. In this article, we present the case of a 31-year-old woman who was in her second trimester of pregnancy and presented with severe dengue with hematological and neurological complications, and premature labor. She was misdiagnosed with bacterial infection and received antibiotic treatment with no improvement of the clinical manifestations and previous to death, she was diagnosed with dengue infection. She died from cardiorespiratory arrest. In the postmortem evaluation, influenza A co-infection was confirmed and characterization of the tissue damage and immune response in lung, liver, kidney, heart, spleen, and brain was determined, finding a severe inflammatory response in lung with T cells and macrophages infiltrating the tissue. This case report highlights the risks of accepting a single diagnosis, especially in endemic countries to multiple tropical diseases, which can lead to delay in appropriate treatment that could reduce morbidity and mortality. MDPI 2019-05-21 /pmc/articles/PMC6631397/ /pubmed/31117316 http://dx.doi.org/10.3390/tropicalmed4020084 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Guzmán-Rodríguez, Mónica Acosta-Ñañez, Héctor F. Mantilla, Julio César Bonelo, Anilza Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report |
title | Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report |
title_full | Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report |
title_fullStr | Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report |
title_full_unstemmed | Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report |
title_short | Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report |
title_sort | dengue virus and influenza a virus co-infection in pregnancy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631397/ https://www.ncbi.nlm.nih.gov/pubmed/31117316 http://dx.doi.org/10.3390/tropicalmed4020084 |
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