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Psychotropic Drugs for the Management of Chronic Pain and Itch

Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are...

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Autores principales: Belinskaia, Daria A., Belinskaia, Mariia A., Barygin, Oleg I., Vanchakova, Nina P., Shestakova, Natalia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631469/
https://www.ncbi.nlm.nih.gov/pubmed/31238561
http://dx.doi.org/10.3390/ph12020099
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author Belinskaia, Daria A.
Belinskaia, Mariia A.
Barygin, Oleg I.
Vanchakova, Nina P.
Shestakova, Natalia N.
author_facet Belinskaia, Daria A.
Belinskaia, Mariia A.
Barygin, Oleg I.
Vanchakova, Nina P.
Shestakova, Natalia N.
author_sort Belinskaia, Daria A.
collection PubMed
description Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds.
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spelling pubmed-66314692019-08-19 Psychotropic Drugs for the Management of Chronic Pain and Itch Belinskaia, Daria A. Belinskaia, Mariia A. Barygin, Oleg I. Vanchakova, Nina P. Shestakova, Natalia N. Pharmaceuticals (Basel) Review Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit symptoms of increased anxiety, depression and cognitive impairment. Such patients need corrective therapy with antidepressants, antipsychotics or anticonvulsants. It is known that some psychotropic drugs are also effective for the treatment of neuropathic pain and pruritus syndromes due to interaction with the secondary molecular targets. Our own clinical studies have identified antipruritic and/or analgesic efficacy of the following compounds: tianeptine (atypical tricyclic antidepressant), citalopram (selective serotonin reuptake inhibitor), mianserin (tetracyclic antidepressant), carbamazepine (anticonvulsant), trazodone (serotonin antagonist and reuptake inhibitor), and chlorprothixene (antipsychotic). Venlafaxine (serotonin-norepinephrine reuptake inhibitor) is known to have an analgesic effect too. The mechanism of such effect of these drugs is not fully understood. Herein we review and correlate the literature data on analgesic/antipruritic activity with pharmacological profile of these compounds. MDPI 2019-06-24 /pmc/articles/PMC6631469/ /pubmed/31238561 http://dx.doi.org/10.3390/ph12020099 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Belinskaia, Daria A.
Belinskaia, Mariia A.
Barygin, Oleg I.
Vanchakova, Nina P.
Shestakova, Natalia N.
Psychotropic Drugs for the Management of Chronic Pain and Itch
title Psychotropic Drugs for the Management of Chronic Pain and Itch
title_full Psychotropic Drugs for the Management of Chronic Pain and Itch
title_fullStr Psychotropic Drugs for the Management of Chronic Pain and Itch
title_full_unstemmed Psychotropic Drugs for the Management of Chronic Pain and Itch
title_short Psychotropic Drugs for the Management of Chronic Pain and Itch
title_sort psychotropic drugs for the management of chronic pain and itch
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631469/
https://www.ncbi.nlm.nih.gov/pubmed/31238561
http://dx.doi.org/10.3390/ph12020099
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