Cargando…
The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression
The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631508/ https://www.ncbi.nlm.nih.gov/pubmed/31167408 http://dx.doi.org/10.3390/ncrna5020039 |
_version_ | 1783435533450477568 |
---|---|
author | Mudgapalli, Nithya Shaw, Brianna P. Chava, Srinivas Challagundla, Kishore B. |
author_facet | Mudgapalli, Nithya Shaw, Brianna P. Chava, Srinivas Challagundla, Kishore B. |
author_sort | Mudgapalli, Nithya |
collection | PubMed |
description | The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of evidence suggests that T-UCRs contribute to oncogenic pathways. Neuroblastoma is a type of childhood cancer that is challenging to treat. The role of non-coding RNAs in the pathogenesis of neuroblastoma, in particular for cancer development, progression, and therapy resistance, has been documented. Exosmic non-coding RNAs are also involved in shaping the biology of the tumor microenvironment in neuroblastoma. In recent years, the involvement of T-UCRs in a wide variety of pathways in neuroblastoma has been discovered. Here, we present an overview of the involvement of T-UCRs in various cellular pathways, such as DNA damage response, proliferation, chemotherapy response, MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)) amplification, gene copy number, and immune response, as well as correlate it to patient survival in neuroblastoma. |
format | Online Article Text |
id | pubmed-6631508 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66315082019-08-19 The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression Mudgapalli, Nithya Shaw, Brianna P. Chava, Srinivas Challagundla, Kishore B. Noncoding RNA Review The Transcribed-Ultra Conserved Regions (T-UCRs) are a class of novel non-coding RNAs that arise from the dark matter of the genome. T-UCRs are highly conserved between mouse, rat, and human genomes, which might indicate a definitive role for these elements in health and disease. The growing body of evidence suggests that T-UCRs contribute to oncogenic pathways. Neuroblastoma is a type of childhood cancer that is challenging to treat. The role of non-coding RNAs in the pathogenesis of neuroblastoma, in particular for cancer development, progression, and therapy resistance, has been documented. Exosmic non-coding RNAs are also involved in shaping the biology of the tumor microenvironment in neuroblastoma. In recent years, the involvement of T-UCRs in a wide variety of pathways in neuroblastoma has been discovered. Here, we present an overview of the involvement of T-UCRs in various cellular pathways, such as DNA damage response, proliferation, chemotherapy response, MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)) amplification, gene copy number, and immune response, as well as correlate it to patient survival in neuroblastoma. MDPI 2019-06-04 /pmc/articles/PMC6631508/ /pubmed/31167408 http://dx.doi.org/10.3390/ncrna5020039 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mudgapalli, Nithya Shaw, Brianna P. Chava, Srinivas Challagundla, Kishore B. The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression |
title | The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression |
title_full | The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression |
title_fullStr | The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression |
title_full_unstemmed | The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression |
title_short | The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression |
title_sort | transcribed-ultra conserved regions: novel non-coding rna players in neuroblastoma progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631508/ https://www.ncbi.nlm.nih.gov/pubmed/31167408 http://dx.doi.org/10.3390/ncrna5020039 |
work_keys_str_mv | AT mudgapallinithya thetranscribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT shawbriannap thetranscribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT chavasrinivas thetranscribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT challagundlakishoreb thetranscribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT mudgapallinithya transcribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT shawbriannap transcribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT chavasrinivas transcribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression AT challagundlakishoreb transcribedultraconservedregionsnovelnoncodingrnaplayersinneuroblastomaprogression |