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Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE

Transition-metal nanomaterials are very important to non-enzymatic glucose sensing because of their excellent electrocatalytic ability, good selectivity, the fact that they are not easily interfered with by chloride ion (Cl(−)), and low cost. However, the linear detection range needs to be expanded....

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Detalles Bibliográficos
Autores principales: Dai, Zhikuang, Yang, Ailing, Bao, Xichang, Yang, Renqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631518/
https://www.ncbi.nlm.nih.gov/pubmed/31238594
http://dx.doi.org/10.3390/s19122824
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author Dai, Zhikuang
Yang, Ailing
Bao, Xichang
Yang, Renqiang
author_facet Dai, Zhikuang
Yang, Ailing
Bao, Xichang
Yang, Renqiang
author_sort Dai, Zhikuang
collection PubMed
description Transition-metal nanomaterials are very important to non-enzymatic glucose sensing because of their excellent electrocatalytic ability, good selectivity, the fact that they are not easily interfered with by chloride ion (Cl(−)), and low cost. However, the linear detection range needs to be expanded. In this paper, Cu(2)O–bovine serum albumin (BSA) core-shell nanoparticles (NPs) were synthesized for the first time in air at room temperature by a facile and green route. The structure and morphology of Cu(2)O–BSA NPs were characterized. The as-prepared Cu(2)O–BSA NPs were used to modify the glassy carbon electrode (GCE) in a Nafion matrix. By using cyclic voltammetry (CV), the influence from scanning speed, concentration of NaOH, and load of Cu(2)O–BSA NPs for the modified electrodes was probed. Cu(2)O–BSA NPs showed direct electrocatalytic activity for the oxidation of glucose in 50 mM NaOH solution at 0.6 V. The chronoamperometry result showed this constructing sensor in the detection of glucose with a lowest detection limit of 0.4 μM, a linear detection range up to 10 mM, a high sensitivity of 1144.81 μAmM(−1)cm(−2) and reliable anti-interference property to Cl(−), uric acid (UA), ascorbic acid (AA), and acetaminophen (AP). Cu(2)O–BSA NPs are promising nanostructures for the fabrication of non-enzymatic glucose electrochemical sensing devices.
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spelling pubmed-66315182019-08-19 Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE Dai, Zhikuang Yang, Ailing Bao, Xichang Yang, Renqiang Sensors (Basel) Article Transition-metal nanomaterials are very important to non-enzymatic glucose sensing because of their excellent electrocatalytic ability, good selectivity, the fact that they are not easily interfered with by chloride ion (Cl(−)), and low cost. However, the linear detection range needs to be expanded. In this paper, Cu(2)O–bovine serum albumin (BSA) core-shell nanoparticles (NPs) were synthesized for the first time in air at room temperature by a facile and green route. The structure and morphology of Cu(2)O–BSA NPs were characterized. The as-prepared Cu(2)O–BSA NPs were used to modify the glassy carbon electrode (GCE) in a Nafion matrix. By using cyclic voltammetry (CV), the influence from scanning speed, concentration of NaOH, and load of Cu(2)O–BSA NPs for the modified electrodes was probed. Cu(2)O–BSA NPs showed direct electrocatalytic activity for the oxidation of glucose in 50 mM NaOH solution at 0.6 V. The chronoamperometry result showed this constructing sensor in the detection of glucose with a lowest detection limit of 0.4 μM, a linear detection range up to 10 mM, a high sensitivity of 1144.81 μAmM(−1)cm(−2) and reliable anti-interference property to Cl(−), uric acid (UA), ascorbic acid (AA), and acetaminophen (AP). Cu(2)O–BSA NPs are promising nanostructures for the fabrication of non-enzymatic glucose electrochemical sensing devices. MDPI 2019-06-24 /pmc/articles/PMC6631518/ /pubmed/31238594 http://dx.doi.org/10.3390/s19122824 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dai, Zhikuang
Yang, Ailing
Bao, Xichang
Yang, Renqiang
Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE
title Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE
title_full Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE
title_fullStr Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE
title_full_unstemmed Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE
title_short Facile Non-Enzymatic Electrochemical Sensing for Glucose Based on Cu(2)O–BSA Nanoparticles Modified GCE
title_sort facile non-enzymatic electrochemical sensing for glucose based on cu(2)o–bsa nanoparticles modified gce
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631518/
https://www.ncbi.nlm.nih.gov/pubmed/31238594
http://dx.doi.org/10.3390/s19122824
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