Microfluidic Technology for Clinical Applications of Exosomes

Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosom...

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Autores principales: Iliescu, Florina S., Vrtačnik, Danilo, Neuzil, Pavel, Iliescu, Ciprian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631586/
https://www.ncbi.nlm.nih.gov/pubmed/31212754
http://dx.doi.org/10.3390/mi10060392
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author Iliescu, Florina S.
Vrtačnik, Danilo
Neuzil, Pavel
Iliescu, Ciprian
author_facet Iliescu, Florina S.
Vrtačnik, Danilo
Neuzil, Pavel
Iliescu, Ciprian
author_sort Iliescu, Florina S.
collection PubMed
description Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosomes, presents the challenges in exosome research, discusses the potential of exosomes as biomarkers, and describes the contribution of microfluidic technology to enable their isolation and analysis for diagnostic and disease monitoring. Additionally, clinical applications of exosomes for diagnostic purposes are also summarized.
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spelling pubmed-66315862019-08-19 Microfluidic Technology for Clinical Applications of Exosomes Iliescu, Florina S. Vrtačnik, Danilo Neuzil, Pavel Iliescu, Ciprian Micromachines (Basel) Review Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases. This review introduces general aspects of exosomes, presents the challenges in exosome research, discusses the potential of exosomes as biomarkers, and describes the contribution of microfluidic technology to enable their isolation and analysis for diagnostic and disease monitoring. Additionally, clinical applications of exosomes for diagnostic purposes are also summarized. MDPI 2019-06-12 /pmc/articles/PMC6631586/ /pubmed/31212754 http://dx.doi.org/10.3390/mi10060392 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Iliescu, Florina S.
Vrtačnik, Danilo
Neuzil, Pavel
Iliescu, Ciprian
Microfluidic Technology for Clinical Applications of Exosomes
title Microfluidic Technology for Clinical Applications of Exosomes
title_full Microfluidic Technology for Clinical Applications of Exosomes
title_fullStr Microfluidic Technology for Clinical Applications of Exosomes
title_full_unstemmed Microfluidic Technology for Clinical Applications of Exosomes
title_short Microfluidic Technology for Clinical Applications of Exosomes
title_sort microfluidic technology for clinical applications of exosomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631586/
https://www.ncbi.nlm.nih.gov/pubmed/31212754
http://dx.doi.org/10.3390/mi10060392
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