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Tumor mutational burden quantification from targeted gene panels: major advancements and challenges

Tumor mutational burden (TMB), the total number of somatic coding mutations in a tumor, is emerging as a promising biomarker for immunotherapy response in cancer patients. TMB can be quantitated by a number of NGS-based sequencing technologies. Whole Exome Sequencing (WES) allows comprehensive measu...

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Detalles Bibliográficos
Autores principales:	Fancello, Laura, Gandini, Sara, Pelicci, Pier Giuseppe, Mazzarella, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631597/ https://www.ncbi.nlm.nih.gov/pubmed/31307554 http://dx.doi.org/10.1186/s40425-019-0647-4

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