Cargando…

Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs

Recent reports suggest that antibiotic therapy may either reduce or enhance the immune response to various porcine vaccines. Based upon these findings, we asked if antibiotic therapy alters immune cell populations, as measured by flow cytometry and/or vaccine-specific humoral immunity, as measured b...

Descripción completa

Detalles Bibliográficos
Autores principales: Fogle, Jonathan E., Scott, Jenna A., Almond, Glen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631623/
https://www.ncbi.nlm.nih.gov/pubmed/31151211
http://dx.doi.org/10.3390/vetsci6020051
_version_ 1783435560934703104
author Fogle, Jonathan E.
Scott, Jenna A.
Almond, Glen W.
author_facet Fogle, Jonathan E.
Scott, Jenna A.
Almond, Glen W.
author_sort Fogle, Jonathan E.
collection PubMed
description Recent reports suggest that antibiotic therapy may either reduce or enhance the immune response to various porcine vaccines. Based upon these findings, we asked if antibiotic therapy alters immune cell populations, as measured by flow cytometry and/or vaccine-specific humoral immunity, as measured by sample to positive (S/P) antibody ratios. Here, we investigated the immuno-modulatory effects of enrofloxacin, ceftiofur, and tulathromycin on the immune response to a Mycoplasma hyopneumoniae (M. hyopneumoniae) and porcine circovirus type 2 (PCV-2) combination vaccine in weaned pigs. Maternal antibody likely interfered with the induction of immunity to M. hyopneumoniae. Antibiotic administration did not affect immune cell populations, as assessed by flow cytometry and did not affect the induction of humoral immunity to PCV-2.
format Online
Article
Text
id pubmed-6631623
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66316232019-08-19 Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs Fogle, Jonathan E. Scott, Jenna A. Almond, Glen W. Vet Sci Brief Report Recent reports suggest that antibiotic therapy may either reduce or enhance the immune response to various porcine vaccines. Based upon these findings, we asked if antibiotic therapy alters immune cell populations, as measured by flow cytometry and/or vaccine-specific humoral immunity, as measured by sample to positive (S/P) antibody ratios. Here, we investigated the immuno-modulatory effects of enrofloxacin, ceftiofur, and tulathromycin on the immune response to a Mycoplasma hyopneumoniae (M. hyopneumoniae) and porcine circovirus type 2 (PCV-2) combination vaccine in weaned pigs. Maternal antibody likely interfered with the induction of immunity to M. hyopneumoniae. Antibiotic administration did not affect immune cell populations, as assessed by flow cytometry and did not affect the induction of humoral immunity to PCV-2. MDPI 2019-05-30 /pmc/articles/PMC6631623/ /pubmed/31151211 http://dx.doi.org/10.3390/vetsci6020051 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Fogle, Jonathan E.
Scott, Jenna A.
Almond, Glen W.
Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs
title Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs
title_full Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs
title_fullStr Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs
title_full_unstemmed Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs
title_short Antibiotic Therapy Does Not Alter the Humoral Response to Vaccination for Porcine Circovirus 2 in Weaned Pigs
title_sort antibiotic therapy does not alter the humoral response to vaccination for porcine circovirus 2 in weaned pigs
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631623/
https://www.ncbi.nlm.nih.gov/pubmed/31151211
http://dx.doi.org/10.3390/vetsci6020051
work_keys_str_mv AT foglejonathane antibiotictherapydoesnotalterthehumoralresponsetovaccinationforporcinecircovirus2inweanedpigs
AT scottjennaa antibiotictherapydoesnotalterthehumoralresponsetovaccinationforporcinecircovirus2inweanedpigs
AT almondglenw antibiotictherapydoesnotalterthehumoralresponsetovaccinationforporcinecircovirus2inweanedpigs