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APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC

BACKGROUND: Triple negative breast cancer (TNBC) is a breast cancer subgroup characterized by a lack of hormone receptors’ expression and no HER2 overexpression. These molecular features both drastically reduce treatment options and confer poor prognosis. Platinum (Pt)-salts are being investigated a...

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Detalles Bibliográficos
Autores principales:	Malfatti, Matilde Clarissa, Gerratana, Lorenzo, Dalla, Emiliano, Isola, Miriam, Damante, Giuseppe, Di Loreto, Carla, Puglisi, Fabio, Tell, Gianluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631760/ https://www.ncbi.nlm.nih.gov/pubmed/31307523 http://dx.doi.org/10.1186/s13046-019-1294-9

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