A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences

Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or strains which have been used to best characterize...

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Autores principales: Pandya, Mansi C., Callahan, Sean M., Savchenko, Kyryll G., Stobart, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631838/
https://www.ncbi.nlm.nih.gov/pubmed/31117229
http://dx.doi.org/10.3390/pathogens8020067
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author Pandya, Mansi C.
Callahan, Sean M.
Savchenko, Kyryll G.
Stobart, Christopher C.
author_facet Pandya, Mansi C.
Callahan, Sean M.
Savchenko, Kyryll G.
Stobart, Christopher C.
author_sort Pandya, Mansi C.
collection PubMed
description Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or strains which have been used to best characterize the virus since its discovery in 1956, and discuss the implications for genetic and functional variations between the established laboratory strains and the recently identified clinical isolates.
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spelling pubmed-66318382019-08-19 A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences Pandya, Mansi C. Callahan, Sean M. Savchenko, Kyryll G. Stobart, Christopher C. Pathogens Review Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or strains which have been used to best characterize the virus since its discovery in 1956, and discuss the implications for genetic and functional variations between the established laboratory strains and the recently identified clinical isolates. MDPI 2019-05-21 /pmc/articles/PMC6631838/ /pubmed/31117229 http://dx.doi.org/10.3390/pathogens8020067 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pandya, Mansi C.
Callahan, Sean M.
Savchenko, Kyryll G.
Stobart, Christopher C.
A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
title A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
title_full A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
title_fullStr A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
title_full_unstemmed A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
title_short A Contemporary View of Respiratory Syncytial Virus (RSV) Biology and Strain-Specific Differences
title_sort contemporary view of respiratory syncytial virus (rsv) biology and strain-specific differences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631838/
https://www.ncbi.nlm.nih.gov/pubmed/31117229
http://dx.doi.org/10.3390/pathogens8020067
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