Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles

The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we...

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Autores principales: Flockton, Tyler R., Schnorbus, Logan, Araujo, Agustin, Adams, Jill, Hammel, Maryjane, Perez, Lark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631850/
https://www.ncbi.nlm.nih.gov/pubmed/31022836
http://dx.doi.org/10.3390/pathogens8020055
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author Flockton, Tyler R.
Schnorbus, Logan
Araujo, Agustin
Adams, Jill
Hammel, Maryjane
Perez, Lark J.
author_facet Flockton, Tyler R.
Schnorbus, Logan
Araujo, Agustin
Adams, Jill
Hammel, Maryjane
Perez, Lark J.
author_sort Flockton, Tyler R.
collection PubMed
description The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.
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spelling pubmed-66318502019-08-19 Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles Flockton, Tyler R. Schnorbus, Logan Araujo, Agustin Adams, Jill Hammel, Maryjane Perez, Lark J. Pathogens Article The gram-negative bacterial pathogen Pseudomonas aeruginosa represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of P. aeruginosa LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs. MDPI 2019-04-24 /pmc/articles/PMC6631850/ /pubmed/31022836 http://dx.doi.org/10.3390/pathogens8020055 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Flockton, Tyler R.
Schnorbus, Logan
Araujo, Agustin
Adams, Jill
Hammel, Maryjane
Perez, Lark J.
Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles
title Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles
title_full Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles
title_fullStr Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles
title_full_unstemmed Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles
title_short Inhibition of Pseudomonas aeruginosa Biofilm Formation with Surface Modified Polymeric Nanoparticles
title_sort inhibition of pseudomonas aeruginosa biofilm formation with surface modified polymeric nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631850/
https://www.ncbi.nlm.nih.gov/pubmed/31022836
http://dx.doi.org/10.3390/pathogens8020055
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