Cargando…

Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy

Canine mast cell tumours (MCTs) present a wide variety of challenging clinical behaviours in terms of predicting the prognosis and choosing appropriate treatment. This study investigated the frequency, risk, and prognostic factors of MCTs in dogs admitted to a single veterinary teaching hospital (VT...

Descripción completa

Detalles Bibliográficos
Autores principales: Pierini, Alessio, Lubas, George, Gori, Eleonora, Binanti, Diana, Millanta, Francesca, Marchetti, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631885/
https://www.ncbi.nlm.nih.gov/pubmed/31174330
http://dx.doi.org/10.3390/vetsci6020053
_version_ 1783435623383695360
author Pierini, Alessio
Lubas, George
Gori, Eleonora
Binanti, Diana
Millanta, Francesca
Marchetti, Veronica
author_facet Pierini, Alessio
Lubas, George
Gori, Eleonora
Binanti, Diana
Millanta, Francesca
Marchetti, Veronica
author_sort Pierini, Alessio
collection PubMed
description Canine mast cell tumours (MCTs) present a wide variety of challenging clinical behaviours in terms of predicting the prognosis and choosing appropriate treatment. This study investigated the frequency, risk, and prognostic factors of MCTs in dogs admitted to a single veterinary teaching hospital (VTH). Breed, age, sex, and sexual status in ninety-eight dogs with MCTs (MCT-group) were compared with a control group of 13,077 dogs (VTH-group) obtained from the VTH clinical database from January 2010 to January 2016. Within the MCT-group, signalment, location, size, mass number, ulceration, histopathological grading, presence of lymph node, or distant metastases were compared with each other and with the outcome. Boxers (OR 7.2), American Pit Bull Terriers (OR 5.4), French Bulldogs (OR 4.4) and Labrador Retrievers (OR 2.6) were overrepresented. The MCT-group was significantly older than the VTH-group (p < 0.0001). In comparison with the VTH group, in the MCT-group neutered dogs (OR 2.1) and spayed females (OR 2.3) were predominant compared to intact dogs and intact females, respectively. Ulceration (OR 5.2) and lymph node metastasis (OR 7.1) occurred more frequently in larger MCTs. Both ulceration and MCTs > 3 cm were highly associated with lymph node metastasis (OR 24.8). Recurrence was associated with MCT-related death (OR 10.50, p = 0.0040), and the latter was associated with shorter survival times (p = 0.0115). Dogs with MCTs > 3 cm (p = 0.0040), lymph node metastasis (p = 0.0234), or elevated WHO stage (p = 0.0158) had shorter survival times. A significantly higher frequency of MCTs was found in specific breeds, and in older and neutered dogs. MCTs > 3 cm and lymph node or distant metastases were associated with shorter survival times.
format Online
Article
Text
id pubmed-6631885
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-66318852019-08-19 Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy Pierini, Alessio Lubas, George Gori, Eleonora Binanti, Diana Millanta, Francesca Marchetti, Veronica Vet Sci Communication Canine mast cell tumours (MCTs) present a wide variety of challenging clinical behaviours in terms of predicting the prognosis and choosing appropriate treatment. This study investigated the frequency, risk, and prognostic factors of MCTs in dogs admitted to a single veterinary teaching hospital (VTH). Breed, age, sex, and sexual status in ninety-eight dogs with MCTs (MCT-group) were compared with a control group of 13,077 dogs (VTH-group) obtained from the VTH clinical database from January 2010 to January 2016. Within the MCT-group, signalment, location, size, mass number, ulceration, histopathological grading, presence of lymph node, or distant metastases were compared with each other and with the outcome. Boxers (OR 7.2), American Pit Bull Terriers (OR 5.4), French Bulldogs (OR 4.4) and Labrador Retrievers (OR 2.6) were overrepresented. The MCT-group was significantly older than the VTH-group (p < 0.0001). In comparison with the VTH group, in the MCT-group neutered dogs (OR 2.1) and spayed females (OR 2.3) were predominant compared to intact dogs and intact females, respectively. Ulceration (OR 5.2) and lymph node metastasis (OR 7.1) occurred more frequently in larger MCTs. Both ulceration and MCTs > 3 cm were highly associated with lymph node metastasis (OR 24.8). Recurrence was associated with MCT-related death (OR 10.50, p = 0.0040), and the latter was associated with shorter survival times (p = 0.0115). Dogs with MCTs > 3 cm (p = 0.0040), lymph node metastasis (p = 0.0234), or elevated WHO stage (p = 0.0158) had shorter survival times. A significantly higher frequency of MCTs was found in specific breeds, and in older and neutered dogs. MCTs > 3 cm and lymph node or distant metastases were associated with shorter survival times. MDPI 2019-06-06 /pmc/articles/PMC6631885/ /pubmed/31174330 http://dx.doi.org/10.3390/vetsci6020053 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Pierini, Alessio
Lubas, George
Gori, Eleonora
Binanti, Diana
Millanta, Francesca
Marchetti, Veronica
Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
title Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
title_full Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
title_fullStr Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
title_full_unstemmed Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
title_short Epidemiology of Breed-Related Mast Cell Tumour Occurrence and Prognostic Significance of Clinical Features in a Defined Population of Dogs in West-Central Italy
title_sort epidemiology of breed-related mast cell tumour occurrence and prognostic significance of clinical features in a defined population of dogs in west-central italy
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631885/
https://www.ncbi.nlm.nih.gov/pubmed/31174330
http://dx.doi.org/10.3390/vetsci6020053
work_keys_str_mv AT pierinialessio epidemiologyofbreedrelatedmastcelltumouroccurrenceandprognosticsignificanceofclinicalfeaturesinadefinedpopulationofdogsinwestcentralitaly
AT lubasgeorge epidemiologyofbreedrelatedmastcelltumouroccurrenceandprognosticsignificanceofclinicalfeaturesinadefinedpopulationofdogsinwestcentralitaly
AT gorieleonora epidemiologyofbreedrelatedmastcelltumouroccurrenceandprognosticsignificanceofclinicalfeaturesinadefinedpopulationofdogsinwestcentralitaly
AT binantidiana epidemiologyofbreedrelatedmastcelltumouroccurrenceandprognosticsignificanceofclinicalfeaturesinadefinedpopulationofdogsinwestcentralitaly
AT millantafrancesca epidemiologyofbreedrelatedmastcelltumouroccurrenceandprognosticsignificanceofclinicalfeaturesinadefinedpopulationofdogsinwestcentralitaly
AT marchettiveronica epidemiologyofbreedrelatedmastcelltumouroccurrenceandprognosticsignificanceofclinicalfeaturesinadefinedpopulationofdogsinwestcentralitaly