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Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen

The natural population of the aquatic environment supports a diverse aquatic biota and a robust seafood industry. However, this environment also provides an appropriate niche for the growth of pathogenic bacteria that cause problems for human health. For example, species of the genus Vibrio inhabit...

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Autores principales: Acosta-Smith, Erika, Leon-Sicairos, Nidia, Tiwari, Sandeep, Flores-Villaseñor, Hector, Canizalez-Roman, Adrian, Kumavath, Ranjith, Ghosh, Preetam, Azevedo, Vasco, Barh, Debmalya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631886/
https://www.ncbi.nlm.nih.gov/pubmed/31086061
http://dx.doi.org/10.3390/pathogens8020064
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author Acosta-Smith, Erika
Leon-Sicairos, Nidia
Tiwari, Sandeep
Flores-Villaseñor, Hector
Canizalez-Roman, Adrian
Kumavath, Ranjith
Ghosh, Preetam
Azevedo, Vasco
Barh, Debmalya
author_facet Acosta-Smith, Erika
Leon-Sicairos, Nidia
Tiwari, Sandeep
Flores-Villaseñor, Hector
Canizalez-Roman, Adrian
Kumavath, Ranjith
Ghosh, Preetam
Azevedo, Vasco
Barh, Debmalya
author_sort Acosta-Smith, Erika
collection PubMed
description The natural population of the aquatic environment supports a diverse aquatic biota and a robust seafood industry. However, this environment also provides an appropriate niche for the growth of pathogenic bacteria that cause problems for human health. For example, species of the genus Vibrio inhabit marine and estuarine environments. This genus includes species that are pathogenic to aquaculture, invertebrates, and humans. In humans, they can cause prominent diseases like gastroenteritis, wound infections, and septicemia. The increased number of multidrug resistant (MDR) Vibrio strains has drawn the attention of the scientific community to develop new broad-spectrum antibiotics. Hence, in this paper we report the bactericidal effects of compounds derived from Piper betel plants: piperidine, chlorogenic acid, and eugenyl acetate, against various strains of Vibrio species. The different MIC90 values were approximately in a range of 2–6 mg/mL, 5–16 mg/mL, 5–20 mg/mL, and 30–80 mg/mL, for piperidine, chlorogenic acid, and eugenyl acetate, respectively. Piperidine showed the best anti-Vibrio effect against the five Vibrio species tested. Interestingly, combinations of sub-inhibitory concentrations of piperidine, chlorogenic acid, and eugenyl acetate showed inhibitory effects in the Vibrio strains. Furthermore, these compounds showed synergism or partial synergism effects against MDR strains of the Vibrio species when they were incubated with antibiotics (ampicillin and chloramphenicol).
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spelling pubmed-66318862019-08-19 Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen Acosta-Smith, Erika Leon-Sicairos, Nidia Tiwari, Sandeep Flores-Villaseñor, Hector Canizalez-Roman, Adrian Kumavath, Ranjith Ghosh, Preetam Azevedo, Vasco Barh, Debmalya Pathogens Article The natural population of the aquatic environment supports a diverse aquatic biota and a robust seafood industry. However, this environment also provides an appropriate niche for the growth of pathogenic bacteria that cause problems for human health. For example, species of the genus Vibrio inhabit marine and estuarine environments. This genus includes species that are pathogenic to aquaculture, invertebrates, and humans. In humans, they can cause prominent diseases like gastroenteritis, wound infections, and septicemia. The increased number of multidrug resistant (MDR) Vibrio strains has drawn the attention of the scientific community to develop new broad-spectrum antibiotics. Hence, in this paper we report the bactericidal effects of compounds derived from Piper betel plants: piperidine, chlorogenic acid, and eugenyl acetate, against various strains of Vibrio species. The different MIC90 values were approximately in a range of 2–6 mg/mL, 5–16 mg/mL, 5–20 mg/mL, and 30–80 mg/mL, for piperidine, chlorogenic acid, and eugenyl acetate, respectively. Piperidine showed the best anti-Vibrio effect against the five Vibrio species tested. Interestingly, combinations of sub-inhibitory concentrations of piperidine, chlorogenic acid, and eugenyl acetate showed inhibitory effects in the Vibrio strains. Furthermore, these compounds showed synergism or partial synergism effects against MDR strains of the Vibrio species when they were incubated with antibiotics (ampicillin and chloramphenicol). MDPI 2019-05-13 /pmc/articles/PMC6631886/ /pubmed/31086061 http://dx.doi.org/10.3390/pathogens8020064 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Acosta-Smith, Erika
Leon-Sicairos, Nidia
Tiwari, Sandeep
Flores-Villaseñor, Hector
Canizalez-Roman, Adrian
Kumavath, Ranjith
Ghosh, Preetam
Azevedo, Vasco
Barh, Debmalya
Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
title Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
title_full Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
title_fullStr Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
title_full_unstemmed Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
title_short Piper betel Compounds Piperidine, Eugenyl Acetate, and Chlorogenic Acid Are Broad-Spectrum Anti-Vibrio Compounds that Are Also Effective on MDR Strains of the Pathogen
title_sort piper betel compounds piperidine, eugenyl acetate, and chlorogenic acid are broad-spectrum anti-vibrio compounds that are also effective on mdr strains of the pathogen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631886/
https://www.ncbi.nlm.nih.gov/pubmed/31086061
http://dx.doi.org/10.3390/pathogens8020064
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