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Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis

Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival hereditary fibromatosis were treated, and gingival biopsies were obtained....

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Autores principales: Roman-Malo, Lourdes, Bullon, Beatriz, de Miguel, Manuel, Bullon, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631910/
https://www.ncbi.nlm.nih.gov/pubmed/31130610
http://dx.doi.org/10.3390/diseases7020039
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author Roman-Malo, Lourdes
Bullon, Beatriz
de Miguel, Manuel
Bullon, Pedro
author_facet Roman-Malo, Lourdes
Bullon, Beatriz
de Miguel, Manuel
Bullon, Pedro
author_sort Roman-Malo, Lourdes
collection PubMed
description Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival hereditary fibromatosis were treated, and gingival biopsies were obtained. A histological study revealed dense fibrous tissue, basal lamina disruption, and epithelial cell migration into the connective tissue. Fibroblasts were cultured from the father and daughter and compared with those from a healthy control patient. The results of the biochemical analysis showed increased collagen synthesis, reduced antioxidant CoQ(10) content, and high levels of lipid peroxidation. Additionally, fibroblasts culture incubation with the oxidant H(2)O(2) increased collagen levels that have been reduced by the addition of the antioxidant CoQ(10). We conclude that some fibroblasts metabolic alterations play a significant role in initiating and maintaining persistent fibrotic tissue. Oxidative stress influences the fibroblasts collagen production and could play a particular role in the pathogenesis of hereditary gingival fibromatosis.
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spelling pubmed-66319102019-08-19 Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis Roman-Malo, Lourdes Bullon, Beatriz de Miguel, Manuel Bullon, Pedro Diseases Case Report Hereditary gingival fibromatosis is a disorder for which the etiology remains unknown. We aimed to evaluate the fibroblasts and histological alterations to give new clues. A father and a daughter of a family showing gingival hereditary fibromatosis were treated, and gingival biopsies were obtained. A histological study revealed dense fibrous tissue, basal lamina disruption, and epithelial cell migration into the connective tissue. Fibroblasts were cultured from the father and daughter and compared with those from a healthy control patient. The results of the biochemical analysis showed increased collagen synthesis, reduced antioxidant CoQ(10) content, and high levels of lipid peroxidation. Additionally, fibroblasts culture incubation with the oxidant H(2)O(2) increased collagen levels that have been reduced by the addition of the antioxidant CoQ(10). We conclude that some fibroblasts metabolic alterations play a significant role in initiating and maintaining persistent fibrotic tissue. Oxidative stress influences the fibroblasts collagen production and could play a particular role in the pathogenesis of hereditary gingival fibromatosis. MDPI 2019-05-25 /pmc/articles/PMC6631910/ /pubmed/31130610 http://dx.doi.org/10.3390/diseases7020039 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Roman-Malo, Lourdes
Bullon, Beatriz
de Miguel, Manuel
Bullon, Pedro
Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
title Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
title_full Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
title_fullStr Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
title_full_unstemmed Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
title_short Fibroblasts Collagen Production and Histological Alterations in Hereditary Gingival Fibromatosis
title_sort fibroblasts collagen production and histological alterations in hereditary gingival fibromatosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631910/
https://www.ncbi.nlm.nih.gov/pubmed/31130610
http://dx.doi.org/10.3390/diseases7020039
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