Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells

Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shor...

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Detalles Bibliográficos
Autores principales: Miller, Charlotte M., O’Sullivan, Elaine C., McCarthy, Florence O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631919/
https://www.ncbi.nlm.nih.gov/pubmed/31207878
http://dx.doi.org/10.3390/ph12020090
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author Miller, Charlotte M.
O’Sullivan, Elaine C.
McCarthy, Florence O.
author_facet Miller, Charlotte M.
O’Sullivan, Elaine C.
McCarthy, Florence O.
author_sort Miller, Charlotte M.
collection PubMed
description Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects.
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spelling pubmed-66319192019-08-19 Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells Miller, Charlotte M. O’Sullivan, Elaine C. McCarthy, Florence O. Pharmaceuticals (Basel) Article Ellipticines have well documented anticancer activity, in particular with substitution at the 1-, 2-, 6- and 9-positions. However, due to limitations in synthesis and coherent screening methodology the full SAR profile of this anticancer class has not yet been achieved. In order to address this shortfall, we have set out to explore the anticancer activity of this potent natural product by substitution. We currently describe the synthesis of novel 11-substituted ellipticines with two specific derivatives showing potency and diverging cellular growth effects. MDPI 2019-06-14 /pmc/articles/PMC6631919/ /pubmed/31207878 http://dx.doi.org/10.3390/ph12020090 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miller, Charlotte M.
O’Sullivan, Elaine C.
McCarthy, Florence O.
Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
title Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
title_full Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
title_fullStr Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
title_full_unstemmed Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
title_short Novel 11-Substituted Ellipticines as Potent Anticancer Agents with Divergent Activity against Cancer Cells
title_sort novel 11-substituted ellipticines as potent anticancer agents with divergent activity against cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631919/
https://www.ncbi.nlm.nih.gov/pubmed/31207878
http://dx.doi.org/10.3390/ph12020090
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AT mccarthyflorenceo novel11substitutedellipticinesaspotentanticanceragentswithdivergentactivityagainstcancercells

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