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2-Iodo-4′-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway

Methylglyoxal (MG) acts as a reactive precursor of advanced glycation end products (AGEs). This compound is often connected with pathologies such as diabetes, neurodegenerative processes and diseases of aging. 2-iodo-4′-methoxychalcone (CHA79), a synthetic halogen-containing chalcone derivative, has...

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Detalles Bibliográficos
Autores principales:	Tseng, Yu-Ting, Tsai, Yi-Hong, Fülöp, Ferenc, Chang, Fang-Rong, Lo, Yi-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631972/ https://www.ncbi.nlm.nih.gov/pubmed/31208152 http://dx.doi.org/10.3390/molecules24122249

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