Cargando…
Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
BACKGROUND: Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences. Here, we focus on...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631995/ https://www.ncbi.nlm.nih.gov/pubmed/31307522 http://dx.doi.org/10.1186/s13059-019-1750-z |