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A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination

Metal coordination bonds are widely used as the dynamic cross-linkers to construct self-healing hydrogels. However, it remains challenging to independently improve the toughness of metal coordinated hydrogels without affecting the stretchability and self-healing properties, as all these features are...

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Autores principales: Zeng, Liang, Song, Mingming, Gu, Jie, Xu, Zhengyu, Xue, Bin, Li, Ying, Cao, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632049/
https://www.ncbi.nlm.nih.gov/pubmed/31105221
http://dx.doi.org/10.3390/biomimetics4020036
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author Zeng, Liang
Song, Mingming
Gu, Jie
Xu, Zhengyu
Xue, Bin
Li, Ying
Cao, Yi
author_facet Zeng, Liang
Song, Mingming
Gu, Jie
Xu, Zhengyu
Xue, Bin
Li, Ying
Cao, Yi
author_sort Zeng, Liang
collection PubMed
description Metal coordination bonds are widely used as the dynamic cross-linkers to construct self-healing hydrogels. However, it remains challenging to independently improve the toughness of metal coordinated hydrogels without affecting the stretchability and self-healing properties, as all these features are directly correlated with the dynamic properties of the same metal coordination bonds. In this work, using histidine–Zn(2+) binding as an example, we show that the coordination number (the number of binding sites in each cross-linking ligand) is an important parameter for the mechanical strength of the hydrogels. By increasing the coordination number of the binding site, the mechanical strength of the hydrogels can be greatly improved without sacrificing the stretchability and self-healing properties. By adjusting the peptide and Zn(2+) concentrations, the hydrogels can achieve a set of demanding mechanical features, including the Young’s modulus of 7–123 kPa, fracture strain of 434–781%, toughness of 630–1350 kJ m(−3), and self-healing time of ~1 h. We anticipate the engineered hydrogels can find broad applications in a variety of biomedical fields. Moreover, the concept of improving the mechanical strength of metal coordinated hydrogels by tuning the coordination number may inspire the design of other dynamically cross-linked hydrogels with further improved mechanical performance.
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spelling pubmed-66320492019-08-19 A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination Zeng, Liang Song, Mingming Gu, Jie Xu, Zhengyu Xue, Bin Li, Ying Cao, Yi Biomimetics (Basel) Article Metal coordination bonds are widely used as the dynamic cross-linkers to construct self-healing hydrogels. However, it remains challenging to independently improve the toughness of metal coordinated hydrogels without affecting the stretchability and self-healing properties, as all these features are directly correlated with the dynamic properties of the same metal coordination bonds. In this work, using histidine–Zn(2+) binding as an example, we show that the coordination number (the number of binding sites in each cross-linking ligand) is an important parameter for the mechanical strength of the hydrogels. By increasing the coordination number of the binding site, the mechanical strength of the hydrogels can be greatly improved without sacrificing the stretchability and self-healing properties. By adjusting the peptide and Zn(2+) concentrations, the hydrogels can achieve a set of demanding mechanical features, including the Young’s modulus of 7–123 kPa, fracture strain of 434–781%, toughness of 630–1350 kJ m(−3), and self-healing time of ~1 h. We anticipate the engineered hydrogels can find broad applications in a variety of biomedical fields. Moreover, the concept of improving the mechanical strength of metal coordinated hydrogels by tuning the coordination number may inspire the design of other dynamically cross-linked hydrogels with further improved mechanical performance. MDPI 2019-05-10 /pmc/articles/PMC6632049/ /pubmed/31105221 http://dx.doi.org/10.3390/biomimetics4020036 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zeng, Liang
Song, Mingming
Gu, Jie
Xu, Zhengyu
Xue, Bin
Li, Ying
Cao, Yi
A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination
title A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination
title_full A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination
title_fullStr A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination
title_full_unstemmed A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination
title_short A Highly Stretchable, Tough, Fast Self-Healing Hydrogel Based on Peptide–Metal Ion Coordination
title_sort highly stretchable, tough, fast self-healing hydrogel based on peptide–metal ion coordination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632049/
https://www.ncbi.nlm.nih.gov/pubmed/31105221
http://dx.doi.org/10.3390/biomimetics4020036
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