Cargando…

CHCHD4 regulates tumour proliferation and EMT-related phenotypes, through respiratory chain-mediated metabolism

BACKGROUND: Mitochondrial oxidative phosphorylation (OXPHOS) via the respiratory chain is required for the maintenance of tumour cell proliferation and regulation of epithelial to mesenchymal transition (EMT)-related phenotypes through mechanisms that are not fully understood. The essential mitochon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Luke W., Esposito, Cinzia, Stephen, Jenna M., Costa, Ana S. H., Frezza, Christian, Blacker, Thomas S., Szabadkai, Gyorgy, Ashcroft, Margaret
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632184/ https://www.ncbi.nlm.nih.gov/pubmed/31346464 http://dx.doi.org/10.1186/s40170-019-0200-4

Ejemplares similares

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain
por: Thomas, Luke W., et al.
Publicado: (2019)

VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function
por: Briston, Thomas, et al.
Publicado: (2018)

Corrigendum: VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function
por: Briston, Thomas, et al.
Publicado: (2021)

CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria
por: Thomas, Luke W., et al.
Publicado: (2017)

Corrigendum: CHCHD4 Regulates Intracellular Oxygenation and Perinuclear Distribution of Mitochondria
por: Thomas, Luke W., et al.
Publicado: (2019)

CHCHD4 (MIA40) and the mitochondrial disulfide relay system
por: Al-Habib, Hasan, et al.
Publicado: (2021)

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo
por: Erdogan, Alican J., et al.
Publicado: (2018)

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response
por: Ruan, Yu, et al.
Publicado: (2022)

Neurodegeneration-associated mitochondrial proteins, CHCHD2 and CHCHD10–what distinguishes the two?
por: Ikeda, Aya, et al.
Publicado: (2022)

CHCHD2 and CHCHD10: Future therapeutic targets in cognitive disorder and motor neuron disorder
por: Jiang, Tianlin, et al.
Publicado: (2022)

PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction
por: Zhou, Wei, et al.
Publicado: (2019)

CHCHD2 connects mitochondrial metabolism to apoptosis
por: Liu, Yong, et al.
Publicado: (2015)

Twin CHCH Proteins, CHCHD2, and CHCHD10: Key Molecules of Parkinson’s Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
por: Imai, Yuzuru, et al.
Publicado: (2019)

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction
por: Gaude, Edoardo, et al.
Publicado: (2018)

Chchd10 is dispensable for myogenesis but critical for adipose browning
por: Xia, Wei, et al.
Publicado: (2022)

CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion and therapeutic resistance
por: Lumibao, Jan C., et al.
Publicado: (2023)

FRI118 3D Reconstruction Of Mitochondria From Human Heart Failure Structures Is Associated With Alterations In CHCHD6 And CHCHD3 Expression
por: Gail Marshall, Andrea, et al.
Publicado: (2023)

Neuropathologic description of CHCHD10 mutated amyotrophic lateral sclerosis
por: Keith, Julia L., et al.
Publicado: (2020)

CHCHD2: The Power House's Potential Prognostic Factor for Cancer?
por: Gundamaraju, Rohit, et al.
Publicado: (2021)

Fumarate drives EMT in renal cancer
por: Sciacovelli, Marco, et al.
Publicado: (2017)

Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
por: Thomas, Luke W., et al.
Publicado: (2021)

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM
por: Blacker, Thomas S., et al.
Publicado: (2014)

Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure
por: Ding, Chengli, et al.
Publicado: (2015)

A Deletion Downstream of the CHCHD7 Gene Is Associated with Growth Traits in Sheep
por: Xu, Hongwei, et al.
Publicado: (2020)

Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction
por: Lee, Richard G., et al.
Publicado: (2018)

Loss of function CHCHD10 mutations in cytoplasmic TDP-43 accumulation and synaptic integrity
por: Woo, Jung-A. A., et al.
Publicado: (2017)

CHCHD2 promotes hepatocellular carcinoma and indicates poor prognosis of hepatocellular carcinoma patients
por: Yao, Yang, et al.
Publicado: (2019)

Reduced erythrocytic CHCHD2 mRNA is associated with brain pathology of Parkinson’s disease
por: Liu, Xiaodan, et al.
Publicado: (2021)

Serum Creatine, Not Neurofilament Light, Is Elevated in CHCHD10-Linked Spinal Muscular Atrophy
por: Järvilehto, Julius, et al.
Publicado: (2022)

Mitochondrial CHCHD2: Disease-Associated Mutations, Physiological Functions, and Current Animal Models
por: Kee, Teresa R., et al.
Publicado: (2021)

A CHCHD6–APP axis connects amyloid and mitochondrial pathology in Alzheimer’s disease
por: Shang, Yutong, et al.
Publicado: (2022)

Modulation of synaptic plasticity, motor unit physiology, and TDP-43 pathology by CHCHD10
por: Liu, Tian, et al.
Publicado: (2022)

Elevated CHCHD4 orchestrates mitochondrial oxidative phosphorylation to disturb hypoxic pulmonary hypertension
por: Wang, Yu, et al.
Publicado: (2023)

Glutathionylated and Fe–S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain
por: Thiriveedi, Venkata Ramana, et al.
Publicado: (2020)

CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression
por: Yin, Xin, et al.
Publicado: (2020)

Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage
por: Zhang, C., et al.
Publicado: (2017)

Separation of clonogenic tumour cells from EMT6 mouse mammary tumours.
por: Twentyman, P. R., et al.
Publicado: (1977)

Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control
por: Antognelli, Cinzia, et al.
Publicado: (2018)

NF-YAl drives EMT in Claudin(low) tumours
por: Londero, Michela, et al.
Publicado: (2023)

TRAF6 regulates tumour metastasis through EMT and CSC phenotypes in head and neck squamous cell carcinoma
por: Chen, Lei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_mg1sikvbum808hv1df76sr7emc