p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition

BACKGROUND: We reported previously that phenethyl isothiocyanate (PEITC), a dietary compound, can reactivate p53(R175H) mutant in vitro and in SK-BR-3 (p53(R175H)) breast xenograft model resulting in tumor inhibition. Because of the diversity of human cancers with p53 mutations, these findings raise...

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Detalles Bibliográficos
Autores principales: Aggarwal, Monika, Saxena, Rahul, Asif, Nasir, Sinclair, Elizabeth, Tan, Judy, Cruz, Idalia, Berry, Deborah, Kallakury, Bhaskar, Pham, Quynhchi, Wang, Thomas T. Y., Chung, Fung-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6632191/
https://www.ncbi.nlm.nih.gov/pubmed/31307507
http://dx.doi.org/10.1186/s13046-019-1267-z

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