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Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction

Stable recognition of the intron branchpoint (BP) by the U2 snRNP to form the pre-spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from yeast indicate that Cus2 aids U2 snRNA folding into the stem IIa conformation prior to pre-spliceosome formation. Cus2 must the...

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Detalles Bibliográficos
Autores principales:	Talkish, Jason, Igel, Haller, Hunter, Oarteze, Horner, Steven W., Jeffery, Nazish N., Leach, Justin R., Jenkins, Jermaine L., Kielkopf, Clara L., Ares, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633205/ https://www.ncbi.nlm.nih.gov/pubmed/31110137 http://dx.doi.org/10.1261/rna.070649.119

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