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Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features

To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing is highly variable across genes, with some genes even escaping XCI in som...

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Detalles Bibliográficos
Autores principales:	Barros de Andrade e Sousa, Lisa, Jonkers, Iris, Syx, Laurène, Dunkel, Ilona, Chaumeil, Julie, Picard, Christel, Foret, Benjamin, Chen, Chong-Jian, Lis, John T., Heard, Edith, Schulz, Edda G., Marsico, Annalisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633258/ https://www.ncbi.nlm.nih.gov/pubmed/31175153 http://dx.doi.org/10.1101/gr.245027.118

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