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The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance

Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of philly...

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Autores principales: Xu, Xiaoqing, Saadeldeen, Fatma S. A., Xu, Lanting, Zhao, Yingying, Wei, Jinfeng, Wang, Hui-Min David, Liu, Zhenhua, Kang, Wenyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634060/
https://www.ncbi.nlm.nih.gov/pubmed/31355254
http://dx.doi.org/10.1155/2019/3176483
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author Xu, Xiaoqing
Saadeldeen, Fatma S. A.
Xu, Lanting
Zhao, Yingying
Wei, Jinfeng
Wang, Hui-Min David
Liu, Zhenhua
Kang, Wenyi
author_facet Xu, Xiaoqing
Saadeldeen, Fatma S. A.
Xu, Lanting
Zhao, Yingying
Wei, Jinfeng
Wang, Hui-Min David
Liu, Zhenhua
Kang, Wenyi
author_sort Xu, Xiaoqing
collection PubMed
description Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of phillyrin, forsythia ester A, and rosin-β-D-furan glucose on insulin resistance of 3T3-L1 adipocytes were investigated by the method of glucose oxidase-peroxidase (GOD-POD) and the mechanism was assayed by the method of western blot. The results indicated that phillyrin, forsythia ester A, and rosin-β-D-furan glucose could improve the glucose uptake in 3T3-L1 adipocytes under insulin resistance (IR). Among them, phillyrin showed significant activity in increasing glucose consumption at the concentrations of 100 μM and 200 μM (P < 0.001). The mechanism of improving insulin resistance may be that phillyrin could raise the protein phosphorylation of IRS-1 and Akt and the expression levels of GLUT4 protein.
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spelling pubmed-66340602019-07-28 The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance Xu, Xiaoqing Saadeldeen, Fatma S. A. Xu, Lanting Zhao, Yingying Wei, Jinfeng Wang, Hui-Min David Liu, Zhenhua Kang, Wenyi Biomed Res Int Research Article Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of phillyrin, forsythia ester A, and rosin-β-D-furan glucose on insulin resistance of 3T3-L1 adipocytes were investigated by the method of glucose oxidase-peroxidase (GOD-POD) and the mechanism was assayed by the method of western blot. The results indicated that phillyrin, forsythia ester A, and rosin-β-D-furan glucose could improve the glucose uptake in 3T3-L1 adipocytes under insulin resistance (IR). Among them, phillyrin showed significant activity in increasing glucose consumption at the concentrations of 100 μM and 200 μM (P < 0.001). The mechanism of improving insulin resistance may be that phillyrin could raise the protein phosphorylation of IRS-1 and Akt and the expression levels of GLUT4 protein. Hindawi 2019-07-02 /pmc/articles/PMC6634060/ /pubmed/31355254 http://dx.doi.org/10.1155/2019/3176483 Text en Copyright © 2019 Xiaoqing Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xu, Xiaoqing
Saadeldeen, Fatma S. A.
Xu, Lanting
Zhao, Yingying
Wei, Jinfeng
Wang, Hui-Min David
Liu, Zhenhua
Kang, Wenyi
The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
title The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
title_full The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
title_fullStr The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
title_full_unstemmed The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
title_short The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
title_sort mechanism of phillyrin from the leaves of forsythia suspensa for improving insulin resistance
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634060/
https://www.ncbi.nlm.nih.gov/pubmed/31355254
http://dx.doi.org/10.1155/2019/3176483
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