Cargando…
The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance
Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of philly...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634060/ https://www.ncbi.nlm.nih.gov/pubmed/31355254 http://dx.doi.org/10.1155/2019/3176483 |
_version_ | 1783435742908776448 |
---|---|
author | Xu, Xiaoqing Saadeldeen, Fatma S. A. Xu, Lanting Zhao, Yingying Wei, Jinfeng Wang, Hui-Min David Liu, Zhenhua Kang, Wenyi |
author_facet | Xu, Xiaoqing Saadeldeen, Fatma S. A. Xu, Lanting Zhao, Yingying Wei, Jinfeng Wang, Hui-Min David Liu, Zhenhua Kang, Wenyi |
author_sort | Xu, Xiaoqing |
collection | PubMed |
description | Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of phillyrin, forsythia ester A, and rosin-β-D-furan glucose on insulin resistance of 3T3-L1 adipocytes were investigated by the method of glucose oxidase-peroxidase (GOD-POD) and the mechanism was assayed by the method of western blot. The results indicated that phillyrin, forsythia ester A, and rosin-β-D-furan glucose could improve the glucose uptake in 3T3-L1 adipocytes under insulin resistance (IR). Among them, phillyrin showed significant activity in increasing glucose consumption at the concentrations of 100 μM and 200 μM (P < 0.001). The mechanism of improving insulin resistance may be that phillyrin could raise the protein phosphorylation of IRS-1 and Akt and the expression levels of GLUT4 protein. |
format | Online Article Text |
id | pubmed-6634060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66340602019-07-28 The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance Xu, Xiaoqing Saadeldeen, Fatma S. A. Xu, Lanting Zhao, Yingying Wei, Jinfeng Wang, Hui-Min David Liu, Zhenhua Kang, Wenyi Biomed Res Int Research Article Three lignans, phillyrin, forsythia ester A, and rosin-β-D-furan glucose, were isolated from Forsythia suspensa which is a famous Traditional Chinese Medicine used for clearing heat and detoxifying, reducing swelling and dispersing knot, and dispersing wind heat. In this study, the effects of phillyrin, forsythia ester A, and rosin-β-D-furan glucose on insulin resistance of 3T3-L1 adipocytes were investigated by the method of glucose oxidase-peroxidase (GOD-POD) and the mechanism was assayed by the method of western blot. The results indicated that phillyrin, forsythia ester A, and rosin-β-D-furan glucose could improve the glucose uptake in 3T3-L1 adipocytes under insulin resistance (IR). Among them, phillyrin showed significant activity in increasing glucose consumption at the concentrations of 100 μM and 200 μM (P < 0.001). The mechanism of improving insulin resistance may be that phillyrin could raise the protein phosphorylation of IRS-1 and Akt and the expression levels of GLUT4 protein. Hindawi 2019-07-02 /pmc/articles/PMC6634060/ /pubmed/31355254 http://dx.doi.org/10.1155/2019/3176483 Text en Copyright © 2019 Xiaoqing Xu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Xu, Xiaoqing Saadeldeen, Fatma S. A. Xu, Lanting Zhao, Yingying Wei, Jinfeng Wang, Hui-Min David Liu, Zhenhua Kang, Wenyi The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance |
title | The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance |
title_full | The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance |
title_fullStr | The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance |
title_full_unstemmed | The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance |
title_short | The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance |
title_sort | mechanism of phillyrin from the leaves of forsythia suspensa for improving insulin resistance |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634060/ https://www.ncbi.nlm.nih.gov/pubmed/31355254 http://dx.doi.org/10.1155/2019/3176483 |
work_keys_str_mv | AT xuxiaoqing themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT saadeldeenfatmasa themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT xulanting themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT zhaoyingying themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT weijinfeng themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT wanghuimindavid themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT liuzhenhua themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT kangwenyi themechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT xuxiaoqing mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT saadeldeenfatmasa mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT xulanting mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT zhaoyingying mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT weijinfeng mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT wanghuimindavid mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT liuzhenhua mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance AT kangwenyi mechanismofphillyrinfromtheleavesofforsythiasuspensaforimprovinginsulinresistance |