Enhancing Natural Killer and CD8(+) T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8(+) T Cells with HLA-E Monospecific Monoclonal Antibodies

Cytotoxic NK/CD8(+) T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A. The NK/CD8(+) T cell cytotoxic capability is lost when tumor-associated human leukocyte antigen, HLA-E, binds the CD94/NKG2A recept...

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Detalles Bibliográficos
Autores principales: Ravindranath, Mepur H., Filippone, Edward J, Devarajan, Asokan, Asgharzadeh, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634170/
https://www.ncbi.nlm.nih.gov/pubmed/31009335
http://dx.doi.org/10.1089/mab.2018.0043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634170/
https://www.ncbi.nlm.nih.gov/pubmed/31009335
http://dx.doi.org/10.1089/mab.2018.0043

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