Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor

A 24-year-old male with metastatic desmoplastic round cell tumor was admitted for fatigue and weakness after chemotherapy. The patient was found to be hypotensive, pancytopenic, and bacteremic. Early treatment with intravenous antibiotics and fluids was efficacious. The hospital course was complicat...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhuiyan, Nadir, Sharma, Purva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634271/
https://www.ncbi.nlm.nih.gov/pubmed/31328061
http://dx.doi.org/10.7759/cureus.4669
_version_ 1783435753662971904
author Bhuiyan, Nadir
Sharma, Purva
author_facet Bhuiyan, Nadir
Sharma, Purva
author_sort Bhuiyan, Nadir
collection PubMed
description A 24-year-old male with metastatic desmoplastic round cell tumor was admitted for fatigue and weakness after chemotherapy. The patient was found to be hypotensive, pancytopenic, and bacteremic. Early treatment with intravenous antibiotics and fluids was efficacious. The hospital course was complicated by recurrent hypoglycemia that was refractory to the standard hypoglycemia protocol. Initial workup revealed low serum insulin and normal C-peptide. Further evaluation revealed elevated IGF-II levels consistent with non-islet cell tumor-induced hypoglycemia. Euglycemia was subsequently achieved with aggressive and continuous infusion of intravenous 10% dextrose.
format Online
Article
Text
id pubmed-6634271
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-66342712019-07-19 Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor Bhuiyan, Nadir Sharma, Purva Cureus Internal Medicine A 24-year-old male with metastatic desmoplastic round cell tumor was admitted for fatigue and weakness after chemotherapy. The patient was found to be hypotensive, pancytopenic, and bacteremic. Early treatment with intravenous antibiotics and fluids was efficacious. The hospital course was complicated by recurrent hypoglycemia that was refractory to the standard hypoglycemia protocol. Initial workup revealed low serum insulin and normal C-peptide. Further evaluation revealed elevated IGF-II levels consistent with non-islet cell tumor-induced hypoglycemia. Euglycemia was subsequently achieved with aggressive and continuous infusion of intravenous 10% dextrose. Cureus 2019-05-15 /pmc/articles/PMC6634271/ /pubmed/31328061 http://dx.doi.org/10.7759/cureus.4669 Text en Copyright © 2019, Bhuiyan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Bhuiyan, Nadir
Sharma, Purva
Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor
title Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor
title_full Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor
title_fullStr Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor
title_full_unstemmed Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor
title_short Non-islet Cell Tumor-induced Hypoinsulinemic Hypoglycemia in the Setting of Metastatic Desmoplastic Round Cell Tumor
title_sort non-islet cell tumor-induced hypoinsulinemic hypoglycemia in the setting of metastatic desmoplastic round cell tumor
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634271/
https://www.ncbi.nlm.nih.gov/pubmed/31328061
http://dx.doi.org/10.7759/cureus.4669
work_keys_str_mv AT bhuiyannadir nonisletcelltumorinducedhypoinsulinemichypoglycemiainthesettingofmetastaticdesmoplasticroundcelltumor
AT sharmapurva nonisletcelltumorinducedhypoinsulinemichypoglycemiainthesettingofmetastaticdesmoplasticroundcelltumor

Ejemplares similares