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An explanation for origin unwinding in eukaryotes

Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initiate bidirectional forks. How the CMGs melt duplex DNA while encircling it is unknown. Here we show that S. cerevi...

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Detalles Bibliográficos
Autores principales:	Langston, Lance D, O'Donnell, Michael E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634965/ https://www.ncbi.nlm.nih.gov/pubmed/31282859 http://dx.doi.org/10.7554/eLife.46515

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