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Proteome-wide signatures of function in highly diverged intrinsically disordered regions

Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part because the primary amino acid sequences of these regions are poorly conserved in alignments. Here we use an evolutionary approach to detect...

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Detalles Bibliográficos
Autores principales: Zarin, Taraneh, Strome, Bob, Nguyen Ba, Alex N, Alberti, Simon, Forman-Kay, Julie D, Moses, Alan M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634968/
https://www.ncbi.nlm.nih.gov/pubmed/31264965
http://dx.doi.org/10.7554/eLife.46883